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Metformin is used as a first-line therapy for type 2 diabetes, with reports of its usefulness for the prevention and control of several types of cancers. This study investigated the effects of metformin on hepatocellular carcinoma (HCC). The human HCC cell lines HepG2 and PLC/PRF/5 were cultured and treated with metformin or 5-aminoimidazole-4-carboxamide(More)
AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid and cholesterol metabolism. Therefore, AMPK is a key therapeutic target in diabetes. Recent pilot studies have suggested that diabetes drugs may reduce the risk of cancer by affecting the AMPK pathway. However, the association between(More)
Hyperuricaemia is a disorder of purine metabolism, and is strongly associated with insulin resistance and abnormal glucose metabolism. As the producer of insulin, pancreatic β cells might be affected by elevated serum uric acid levels and contribute to the disregulated glucose metabolism. In this study, we investigated the effect of high uric acid on rat(More)
Virtual Instrument (VI) is one of the most prevalent technologies in the domain of testing, control and fault diagnosis systems, etc. In order to update entirely the means of the equipment testing for shipboard equipment, the fault diagnostic system for shipboard equipment is developed, based on VI technology, Delphi and database. The performance and(More)
Multi-sensors Information Fusion (MSIF) technology, is being widely applied to various fields, particularly, the modern military field. In order to enhance the capability of ship chemical defense support in the future informationalization sea warfare, a review of the study and application about MSIF technology in Naval Ships Chemical Detection (NSCD) field(More)
Steroid-induced femoral head necrosis is claimed to be an ischemic femoral head disease. But there is no discussion on the role of nitric oxide (NO) in the idiopathic disease. The concentration of NO indirectly in serum with steroid induced avascular necrosis of femoral head (ANFH) and in controls are studied in this article.