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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
TLDR
This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI and the sex-specificity of Genetic Investigation of Anthropometric Traits (GIANT) Consortium, and it is confirmed that this effect is related to weight change with age or the sexually dimorphism of body shape. Expand
A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
TLDR
A meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals ofAfrican ancestry provides strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. Expand
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
TLDR
The loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. Expand
A comprehensive family-based replication study of schizophrenia genes.
TLDR
A meta-analysis of genome-wide association studies involving 1,085,772 single-nucleotide polymorphisms (SNPs) and 6 databases that showed significant informativeness for SCZ replicated novel SCZ disease genes and pathogenic pathways. Expand
Genome-wide association study of antipsychotic induced QTc interval prolongation
TLDR
The potential of GWAS to discover genes and pathways that mediate antipsychotic-induced QT prolongation is demonstrated and it is demonstrated that some genes may also be unique for drug-induced prolongation. Expand
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
TLDR
A meta-analysis of genome-wide association studies for whole body lean body mass and five novel genetic loci to be significantly associated is performed and provides new insight into the genetics ofLean body mass. Expand
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
TLDR
This is the first report linking TGFA to human OA, which may serve as a new target for future therapies and two loci known to be associated with cartilage thickness are confirmed. Expand
Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis
TLDR
Results from GWAS and functional studies provided suggestive links between IGFBP3 and HOA and suggested that this SNP or a variant in linkage disequilibrium could be an IGF BP3 regulatory variant. Expand
Genome‐Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians
TLDR
A genome‐wide association study of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well‐characterized North American cohorts, and replication analysis of previously reported OA loci are performed. Expand
A survey of genetic simulation software for population and epidemiological studies
A number of programs have been developed for simulating population genetic and genetic epidemiological data conforming to one of three main algorithmic approaches: 'forwards', 'backwards' andExpand
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