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Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features
TLDR
The study not only supports the biological hypothesis that chromatin can regulate expression of tissue-specific or developmental stage-specific lncRNAs but also reveals the discriminating features between lnc RNA and coding genes, which would guide further lncRNA identifications and characterizations.
MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3
TLDR
It is found that miR-137 is up-regulated in human bladder cancer tissues and cell lines and associated with pM or pTNM stage in clinical bladder cancer patients.
Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data
Long non-coding RNAs (lncRNAs) as a key group of non-coding RNAs have gained widely attention. Though lncRNAs have been functionally annotated and systematic explored in higher mammals, few are under
Novel circRNA_0071196/miRNA-19b-3p/CIT axis is associated with proliferation and migration of bladder cancer
TLDR
Findings indicate that circRNA-0071196 upregulates CIT levels in BCa by sponging off miRNA-19b-3p/CIT axis is a potential therapeutic target inBCa.
Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma.
TLDR
The present study was the first, to the best of the authors' knowledge, to demonstrate that TRIM52‑AS1 functions as a tumor suppressor in RCC.
Additive antitumoral effect of interleukin-12 gene therapy and chemotherapy in the treatment of urothelial bladder cancer in vitro and in vivo
TLDR
The combination of THP chemotherapy and IL-12 gene therapy showed an additive antitumoral effect on bladder cancer cells in vitro and in vivo.
Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis
TLDR
The results indicate that proto-oncogene dbl is not a major target for sporadic TGCTs, however, the rare SNP in dbl may affect the susceptibility to undescended testis.
Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors
TLDR
It is emphasized that circRNA can be used as a promising target gene to improve drug resistance and therapeutic efficacy in tumors, especially lung cancer and gastric cancer.
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