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Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
The present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models and assess the changes of brain monoaminergic neurotransmitters after chronic flavonoid administration.
Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder.
The findings from the current study showed that YL-IPA08, a potent and selective TSPO ligand, had a clear anti-PTSD-like effect, which might be partially mediated by binding to T SPO and the subsequent synthesis of allopregnanolone.
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang
Inhibition of N-methyl-D-aspartate receptor function appears to be one of the common actions for antidepressants
It is suggested that inhibition on the function of NMDA–Ca2 –NOS signal pathway appears to be one of the common actions for antidepressants despite their remarkably different structures, which is expected to have great implication for the evaluation and screening in vitro of new antidepressants.
Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice
It is found that agmatine increases proliferation of hippocampal progenitor cells in vitro and the hippocampal neurogenesis in vivo in chronically stressed mice, which may be one of the important mechanisms involved in ag matine's antidepressant action.
Anxiolytic effects of ketamine in animal models of posttraumatic stress disorder
The results suggest that ketamine exerts a therapeutic effect on PTSD that might be at least partially mediated by an influence on BDNF signaling in the hippocampus.
Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
Up-regulation of the proliferation of hippocampal progenitor cells is one of the action mechanisms for MOC, which may be closely related to the elevation of BDNF level at the same time.