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The human immunodeficiency virus (HIV)-1 protein Vif has a central role in the neutralization of host innate defences by hijacking cellular proteasomal degradation pathways to subvert the antiviral activity of host restriction factors; however, the underlying mechanism by which Vif achieves this remains unclear. Here we report a crystal structure of the(More)
The transition metal cobalt, an essential cofactor for many enzymes in prokaryotes, is taken up by several specific transport systems. The CbiMNQO protein complex belongs to type-1 energy-coupling factor (ECF) transporters and is a widespread group of microbial cobalt transporters. CbiO is the ATPase subunit (A-component) of the cobalt transporting system(More)
One-dimensional flexible supercapacitor yarns are of considerable interest for future wearable electronics. The bottleneck in this field is how to develop devices of high energy and power density, by using economically viable materials and scalable fabrication technologies. Here we report a hierarchical graphene-metallic textile composite electrode concept(More)
The energy-coupling factor (ECF) transporters are multi-subunit protein complexes that mediate uptake of transition-metal ions and vitamins in about 50% of the prokaryotes, including bacteria and archaea. Biological and structural studies have been focused on ECF transporters for vitamins, but the molecular mechanism by which ECF systems transport metal(More)
We have used the histochemical and immunohistochemical staining methods and maps of gene expression to analyze the structure of the inferior olive of the C57BL mouse. As in other mammals, the inferior olive of the C57BL mouse contains three major nuclei, the medial nucleus, the principal nucleus, and the dorsal nucleus. The medial nucleus can be divided(More)
To determine if cetuximab combined with chemotherapy is beneficial for patients with advanced NSCLC after failure of first-line chemotherapy and EGFR-tyrosine kinase inhibitors (TKI). Twenty patients were treated with cetuximab in combination with pemetrexed, and 14 patients were treated with cetuximab in combination with docetaxel. Short-term response(More)
Matrix-assisted catalytic printing (MACP) is developed as a low-cost and versatile printing method for the fabrication of multiscale metal conductors on a wide variety of plastic, elastomeric, and textile substrates. Highly conductive Cu interconnects (2.0 × 10⁸ S/m) fabricated by MACP at room temperature display excellent flexibility, foldability, and(More)
Three-dimensional (3D) conductive composites with remarkable flexibility, compressibility, and stretchability are fabricated by solution deposition of thin metal coatings on chemically modified, macroscopically continuous, 3D polyurethane sponges, followed by infiltration of the metallic sponges with polydimethylsiloxane (PDMS). These low-cost conductive(More)
A VR simulator provides low-cost, realistic training for intracardiac techniques for determining the heart's mechanical and electrical activities. A geometric method models interaction between a catheter and the heart wall. Boundary-enhanced voxelization accelerates detection of catheter-heart interaction. A tactile interface incorporates a VR catheter unit(More)