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Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic β-cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the microRNA (miR)-7/7ab family member miR-7a is enriched in mouse adult pancreatic islets compared with miR-7b. Remarkably, miR-7a targets five components of the mTOR signaling(More)
Propagating trust/distrust from a set of seed (good/bad) pages to the entire Web has been widely used to combat Web spam. It has been mentioned that a combined use of good and bad seeds can lead to better results. However, little work has been known to realize this insight successfully. A serious issue of existing algorithms is that trust/distrust is(More)
microRNAs (miRNAs) are non-coding small RNAs (sRNAs) capable of negatively regulating gene expression. Recently, microRNA-like small RNAs (milRNAs) were discovered in several filamentous fungi but not yet in Trichoderma reesei, an industrial filamentous fungus that can secrete abundant hydrolases. To explore the presence of milRNA in T. reesei and evaluate(More)
The adult brain shows remarkable plasticity, as demonstrated by the improvement in most visual discrimination tasks after intensive practice. However, previous studies have demonstrated that practice improved the discrimination only around oblique orientations, while performance around cardinal orientations (vertical or horizontal orientations) remained(More)
To investigate the influence of task difficulty on the neural mechanisms of visual perceptual learning, we recorded event-related potentials (ERPs) from human adults while they were trained with either an easy or a difficult orientation discrimination task. The discrimination thresholds of participants trained with the difficult task decreased after(More)
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are needed urgently to treat the progressively debilitating musculoskeletal disease fibrodysplasia ossificans(More)
A novel chaotic neural network K-set has been constructed based in research on biological olfactory systems. This non-convergent neural network simulates the capacities of biological brains for signal processing in pattern recognition. Its accuracy and efficiency are demonstrated in this report on an application to human face recognition, with comparisons(More)
A large number of solutions have been proposed to support mobility in IP networks including original Mobile IP, its derivatives and several newly proposed protocols. However, these solutions have drawbacks in different aspects including triangle routing, handover inefficiency, heavy signaling overhead, etc. In this paper, we argue that these problems can be(More)