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Hematopoietic growth factors pass through the blood–brain barrier in intact rats
- Li-ru Zhao, Yot Navalitloha, S. Singhal, J. Mehta, D. Groothuis
- Biology, Medicine
- Experimental Neurology
- 1 April 2007
We have previously demonstrated that receptors for hematopoietic growth factors, stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are expressed in the neurons and the neural… Expand
Therapeutic implications of tumor interstitial fluid pressure in subcutaneous RG-2 tumors.
- Yot Navalitloha, E. S. Schwartz, Elizabeth N Groothuis, C. Allen, R. Levy, D. Groothuis
- 1 July 2006
Increased interstitial fluid pressure (IFP) in brain tumors results in rapid removal of drugs from tumor extracellular space. We studied the effects of dexamethasone and hypothermia on IFP in s.c.… Expand
Comparative pharmacokinetics of 14C-sucrose in RG-2 rat gliomas after intravenous and convection-enhanced delivery.
We compared tissue and plasma pharmacokinetics of 14C-sucrose in subcutaneous RG-2 rat gliomas after administration by 3 routes, intravenous bolus (i.v.-B; 50 microCi over 30 s), continuous i.v.… Expand
Isolation of drug delivery from drug effect: problems of optimizing drug delivery parameters.
A recurring question in the treatment of malignant brain tumors has been whether treatment failure is due to inadequate delivery or ineffective drugs. To isolate these issues, we tested a paradigm in… Expand