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We propose a new model of two-sided matching markets, which allows for complex heterogeneous preferences, but is more tractable than the standard model, yielding rich comparative statics and new results on large matching markets. We simplify the standard Gale and Shapley (1962) model in two ways. First, following Aumann (1964) we consider a setting where a(More)
The Boston mechanism is among the most popular school choice procedures in use. Yet, the mechanism has been criticized for its poor incentive and welfare performances, which led the Boston Public Schools to recently replace it with Gale and Shapley's deferred acceptance algorithm (henceforth, DA). The DA elicits truthful revelation of " ordinal "(More)
We synthesized a galactose derivative, N-octyl-4-epi-beta-valienamine (NOEV), for a molecular therapy (chemical chaperone therapy) of a human neurogenetic disease, beta-galactosidosis (GM1-gangliosidosis and Morquio B disease). It is a potent inhibitor of lysosomal beta-galactosidase in vitro. Addition of NOEV in the culture medium restored mutant enzyme(More)
BACKGROUND C-reactive protein (CRP) was an independent prognostic factor for metastatic renal cell carcinoma in the cytokine era. However, the impact of CRP on the survival of metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors has not yet been investigated. Therefore, we further evaluated the prognostic impact of CRP for(More)
CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize alpha2-6-sialylated glycan as a specific ligand. Here we propose that the alpha2-6-sialylated and 6-GlcNAc-sulfated determinant serves as a preferred ligand for CD22 because the binding of a human B-cell line to CD22 was almost completely abrogated after incubating(More)
INTRODUCTION Self-directed learning (SDL) has been an essential issue in medical education due to the expansion of knowledge, accessibility to information and greater emphasis on reflection. If SDL in educational research lacks a clear definition, terminological confusion may hinder the application of the results to practice. The aim of this study was to(More)
OBJECTIVE To verify the prognostic impact of C-reactive protein (CRP) for patients with castration-resistant prostate cancer (CRPC) treated with docetaxel in a single institution. METHODS A group of 80 consecutive patients with CRPC were treated with docetaxel in our institution from January 2005 to May 2010. The patients received 75 mg/m(2) of docetaxel(More)
This paper considers the matching problem with regional quotas, in particular, regional minimum quotas. Although such quotas are relevant in many real-world settings, there is a lack of strategy-proof mechanisms that consider regional minimum quotas. We first show that without any restrictions on the region structure, finding a feasible matching that(More)