Yosuke Uchiyama

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Regenerating islets can be induced by the administration of poly(ADP-ribose) synthetase inhibitors to 90% depancreatized rats. In screening a regenerating isletderived cDNA library, we previously isolated a novel gene, reg (regenerating gene), which encodes a 165-amino acid protein with a 21-amino acid signal sequence. In the present study, we have examined(More)
M. Ackermann, M. Ajello, A. Albert,* A. Allafort, L. Baldini, G. Barbiellini, D. Bastieri, K. Bechtol, R. Bellazzini, E. Bissaldi, E. D. Bloom, E. Bonamente, E. Bottacini, T. J. Brandt, J. Bregeon, M. Brigida, P. Bruel, R. Buehler, S. Buson, G.A. Caliandro, R. A. Cameron, P. A. Caraveo, J.M. Casandjian, C. Cecchi, E. Charles, R. C. G. Chaves, A. Chekhtman,(More)
College of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 310-8512, Japan email: katagiri@mx.ibaraki.ac.jp Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova, Italy Dipartimento di Fisica “G. Galilei”, Università di Padova, I-35131 Padova, Italy Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique,(More)
We report the detection of high energy γ-ray emission from the young and energetic pulsar PSR B1509−58 and its pulsar wind nebula (PWN) in the composite supernova remnant SNR G320.4−1.2 (aka MSH 15−52). Using 1 year of survey data with the Fermi-Large Area Telescope (LAT), we detected pulsations from PSR B1509−58 up to 1 GeV and extended γ-ray emission(More)
Chromogranins (Cg)/secretogranins (Sg) are representative acidic glycoproteins in secretory granules of many endocrine cells where they are co-stored and co-released with resident amines or peptides. The exact distribution of these proteins in the rat anterior pituitary is unknown. Therefore, pituitaries from untreated male rats were investigated by light-(More)
The light and electron microscopic study of the lysosomal marker enzymes acid phosphatase (ACPase), β-d-glucuronidase and arylsulphatase parallelly performed on rat livers obtained during a 24-h span yielded the following results: 1. Lysosomal reactions of these three marker enzymes are subjected to significant circadian variations. 2. The lysosome(More)
Cathepsins B and H are representative cysteine proteinases localized to lysosomes of a variety of mammalian cells. Previous studies indicated the presence of these enzymes also in secretory granules of endocrine cells. Therefore, the human endocrine pancreas and human insulinomas were investigated by light microscopical immunohistochemistry on serial(More)
Cathepsins B, H, and L are representative cysteine proteinases in lysosomes of a large variety of cells. Previous immunochemical studies indicated the presence of these enzymes also in the gastrointestinal wall. Using specific antisera, the cellular and subcellular distribution of cathepsins B, H, and L in rat gastric (oxyntic and pyloric part) and duodenal(More)
This is the first of a series of papers aimed at characterizing the populations detected in the high-latitude sky of the Fermi-LAT survey. In this work we focus on the intrinsic spectral and flux properties of the source sample. We show that when selection effects are properly taken into account, Fermi sources are on average steeper than previously found(More)
This is the first report of Fermi Gamma-ray Space Telescope observations of the quasar 3C 454.3, which has been undergoing pronounced long-term outbursts since 2000. The data from the Large Area Telescope (LAT), covering 2008 July 7– October 6, indicate strong, highly variable γ-ray emission with an average flux of ∼ 3×10 photons cm s, for energies >(More)