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  • Jun Imagawa, Hidekazu Tanaka, +23 authors Shinya Kimura
  • Medicine
  • The Lancet. Haematology
  • 2015 (First Published: 1 December 2015)
  • BACKGROUND First-line imatinib treatment can be successfully discontinued in patients with chronic myeloid leukaemia after deep molecular response has been sustained for at least 2 years. WeContinue Reading
  • Naoto Takahashi, Tetsuzo Tauchi, +29 authors Tomoki Naoe
  • Medicine
  • International Journal of Hematology
  • 2017 (First Published: 1 February 2018)
  • The objective of this prospective clinical trial (JALSG-STIM213, UMIN000011971) was to evaluate treatment-free remission (TFR) rates after discontinuation of imatinib in chronic myeloid leukemiaContinue Reading
  • Yosuke Minami, Kazuhito Yamamoto, Hitoshi Kiyoi, Ryuzo Ueda, Hidehiko Saito, Tomoki Naoe
  • Biology, Medicine
  • Blood
  • 2003 (First Published: 15 October 2003)
  • An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with acute myeloid leukemia (AML) and is correlated with leukocytosis and aContinue Reading
  • Keisuke Watanabe, Yosuke Minami, Yukiyasu Ozawa, Koichi Miyamura, Tomoki Naoe
  • Medicine
  • Anticancer research
  • 2012 (First Published: 1 May 2012)
  • T315I mutation in BCR-ABL causes resistance to therapy with tyrosine kinase inhibitors (TKIs) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cases. We report three casesContinue Reading