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Differential involvement of phosphatidylinositol 3‐kinase‐related protein kinases in hyperphosphorylation of replication protein A2 in response to replication‐mediated DNA double‐strand breaks
Replication protein A2 (RPA2), a component of the RPA heterotrimer, is hyperphosphorylated and forms nuclear foci in response to camptothecin (CPT) that directly induces replication‐mediated DNAExpand
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Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells
Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability, although the mechanisms byExpand
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  • Open Access
DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during theExpand
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  • Open Access
Phosphorylation of histone H2AX at M phase in human cells without DNA damage response.
A variant of histone H2A, H2AX, is phosphorylated on Ser139 in response to DNA double-strand breaks (DSBs), and clusters of the phosphorylated form of H2AX (gamma-H2AX) in nuclei of DSB-induced cellsExpand
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