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BACKGROUND Proton-pump inhibitors such as omeprazole are a standard treatment to prevent non-steroidal anti-inflammatory drug-induced upper gastrointestinal mucosal injuries. However, it is unclear which drugs may protect against all NSAID-induced digestive-tract injuries. Here, we compare the efficacy of the gastromucoprotective drug irsogladine with(More)
The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. Treatment with an exogenous GLP-2 analogue increases intestinal villous mass and prevents intestinal injury. Since GLP-2 is rapidly degraded by dipeptidyl peptidase 4 (DPP4), DPP4 inhibition may(More)
Motor learning has traditionally been associated with the concept of automaticity. Automaticity refers to the reduction of the cognitive effort required to perform a motor task, as learning progresses. However, there is little detailed consensus in the literature on what the process of automatization actually involves. We measured tracking performance in(More)
We measured tracking performance in two groups while either the target or the manual cursor was suppressed for a brief period during each trial. We have used this approach to investigate the internal models used during tracking, and their updating during motor learning. We have simultaneously measured tracking performance and pupil dilation as a measure of(More)
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