Yoshiyuki Tsuda

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OBJECTIVE We attempted to clarify the influence of polymorphisms of nuclear receptors on carbamazepine therapy. PARTICIPANTS AND METHODS The common polymorphisms of nuclear receptors--a tentative pregnane X receptor (PXR)*1B, hepatocyte nuclear factor 4α (HNF4α) rs2071197 (c.115+308G>A), and cytochrome P450 3A5*3 polymorphisms--were genotyped in 168(More)
BACKGROUND Clobazam (CLB) is a 1,5-benzodiazepine with antiepileptic properties. More than 70% of administered CLB is dealkylated to yield N-desmethylclobazam (N-CLB), a pharmacologically active metabolite, by cytochrome P450 (CYP) 3A4 and CYP2C19. The subsequent inactivation of N-CLB is primarily catalyzed by CYP2C19. Meanwhile, P450 oxidoreductase (POR)(More)
OBJECTIVE To clarify the effects of smoking on the disposition of two commonly used antipsychotics, olanzapine and clozapine, and to create standards to adjust the doses of these drugs in clinical practice based on the smoking status. DESIGN A meta-analysis was conducted by searching MEDLINE, Scopus and the Cochrane Library for relevant prospective and(More)
We study how well answer to the question " Is the given quantum state equal to a certain maximally entangled state? " using LOCC, in the context of hypothesis testing. Under several locality and invariance conditions, optimal tests will be derived for several special cases by using basic theory of group representations. Some optimal tests are realized by(More)
Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, healthy, non-smoking males were assessed for(More)
  • Y Tsuda
  • 1989
The present experiments investigated whether rats could selectively retain the necessary spatial information and forget the unnecessary one in the radial arm maze task. In Experiment 1, rats were trained in a directed forgetting preparation in which the test choice was made following the R-cue and not following the F-cue. The performance on the probe tests,(More)