Yoshiyuki Tsuda

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BACKGROUND Clobazam (CLB) is a 1,5-benzodiazepine with antiepileptic properties. More than 70% of administered CLB is dealkylated to yield N-desmethylclobazam (N-CLB), a pharmacologically active metabolite, by cytochrome P450 (CYP) 3A4 and CYP2C19. The subsequent inactivation of N-CLB is primarily catalyzed by CYP2C19. Meanwhile, P450 oxidoreductase (POR)(More)
We study how well answer to the question “Is the given quantum state equal to a certain maximally entangled state?” using LOCC, in the context of hypothesis testing. Under several locality and invariance conditions, optimal tests will be derived for several special cases by using basic theory of group representations. Some optimal tests are realized by(More)
As the commercial use of the Internet becomes common and the demand for mobile computing through the Internet is emerging, it is necessary to construct a secure mobile environment. This paper presents an implementation example of such a system: "Network CryptoGate (NCG)", which employs the IETF/Mobile IP and the IETF/IP security on stationary security(More)
OBJECTIVE We attempted to clarify the influence of polymorphisms of nuclear receptors on carbamazepine therapy. PARTICIPANTS AND METHODS The common polymorphisms of nuclear receptors--a tentative pregnane X receptor (PXR)*1B, hepatocyte nuclear factor 4α (HNF4α) rs2071197 (c.115+308G>A), and cytochrome P450 3A5*3 polymorphisms--were genotyped in 168(More)
OBJECTIVE To clarify the effects of smoking on the disposition of two commonly used antipsychotics, olanzapine and clozapine, and to create standards to adjust the doses of these drugs in clinical practice based on the smoking status. DESIGN A meta-analysis was conducted by searching MEDLINE, Scopus and the Cochrane Library for relevant prospective and(More)
Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, healthy, non-smoking males were assessed for(More)
The purpose of the present experiment was to compare the performance of rats in a win-shift task and a win-stay task in a radial arm maze. To this end, three experiments were conducted using a variety of procedures. In general, the win-shift task required the rats to choose the unvisited arms and the win-stay task required the rats to return the visited(More)