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Overcredibility of molecular phylogenies obtained by Bayesian phylogenetics
TLDR
It is shown by computer simulation that posterior probabilities in Bayesian analysis can be excessively liberal when concatenated gene sequences are used, whereas bootstrap probabilities in neighbor-joining and maximum likelihood analyses are generally slightly conservative.
Phylogenetic analysis of the complete genome of 18 Norwalk-like viruses.
TLDR
The clustering based on the capsid N/S domain successfully distinguished the NLV as well as the groupingbased on the antigenicity, as determined by both antigen and antibody ELISAs with recombinant virus-like particles.
Daclatasvir Plus Asunaprevir for Chronic HCV Genotype 1b Infection
TLDR
Interferon‐free, ribavirin‐free all‐oral therapy with daclatasvir and asunaprevir for 24 weeks is well tolerated and can achieve a high rate of SVR in patients with HCV genotype 1b who were ineligible, intolerant, or had not responded to prior interferon-based therapy.
A Large Variation in the Rates of Synonymous Substitution for RNA Viruses and Its Relationship to a Diversity of Viral Infection and Transmission Modes
TLDR
The results show that the variation of synonymous substitution rates has been influenced most by either the difference in the infection modes or the differences in the transmission modes, which are affected strongly by the infection and transmission modes.
Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor
TLDR
1–deoxy–galactonojirimycin (DGJ), a potent competitive inhibitor of α–Gal A, effectively enhanced α-Gal A activity in Fabry lymphoblasts, when administrated at concentrations lower than that usually required for intracellular inhibition of the enzyme.
Long‐term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection
TLDR
Long‐term ETV treatment may reduce the incidence of HCC in HBV‐infected patients, and the treatment effect was greater in patients at higher risk of H CC.
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.
TLDR
Activation of the PI3K pathway is significantly associated with increasing tumor grade, decreased levels of apoptosis, and with adverse clinical outcome in human gliomas.
Natural selection on the influenza virus genome.
TLDR
The frequency of escape mutant generation appeared to be positively correlated with the d(N/d(S) (D(N)/D(S)) values for the targets of vaccines and drugs, suggesting that the amino acid sites under strong functional constraint are suitable targets.
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
TLDR
The involvement of DSB repair in PD-L1 expression is revealed and mechanistic insight is provided into howPD-L 1 expression is regulated after DSBs, which requires ATM/ATR/Chk1 kinases and IRF1 signalling.
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