Yoshiyuki Sawai

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UNLABELLED Nonalcoholic fatty liver disease (NAFLD) is a growing medical problem around the world. NAFLD patients with nonalcoholic steatohepatitis (NASH) can develop cirrhosis and hepatocellular carcinoma. The ability to distinguish NASH from simple steatosis would be of great clinical significance. Ballooning hepatocytes are characteristic of typical(More)
Most leguminous plants close their leaves in the evening, as if to sleep, and open them early in the morning according to the circadian rhythm controlled by a biological clock. Extensive studies on nyctinastic plants led to the isolation of a variety of leaf-closing and-opening substances. And we found that the biological clock regulates the balance of(More)
In order to obtain vitamin D derivatives, which have strong activity for enhancing bone growth, we designed vitamin D derivatives with various substitutions at the C-2 position. Novel 2 α-substituted vitamin D derivatives were synthesized starting from d-glucose as a chiral template of the A-ring with a CD-ring bromoolefin unit using the Trost coupling(More)
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