Yoshiyuki Nakai

Learn More
BACKGROUND AND AIM Endocytic retrieval of multidrug resistance protein 2 (MRP2) is closely associated with cholestasis and may be attributed to the disturbed linking of MRP2 and radixin, a cross-linker between actin filaments and membrane proteins. This study aimed to investigate the role of radixin in the altered localization of MRP2 in various human(More)
Synovial sarcomas are exceedingly rare neoplasms of the digestive tract. We herein report a case of a synovial sarcoma occurring in the esophagus of a 20-year-old man. He had a history of acute lymphocytic leukemia and had undergone aggressive chemotherapy between the ages of 4 and 8 years. The tumor, which was large and extended into the upper mediastinum,(More)
PURPOSE To determine whether dopamine receptor stimulation regulates Na,K-ATPase-mediated ion transport in cultured nonpigmented ciliary epithelium (NPE). METHODS Using a rabbit NPE cell line, active Na-K transport activity was determined by measuring ouabain-sensitive potassium (86Rb) uptake in cell monolayers. Western blot analysis of membrane material(More)
PURPOSE To characterize the type of reactive oxygen species (ROS) produced by excimer photoablation of aqueous solutions and to show the effects of ROS and antioxidants on corneal stromal cells in vitro. METHODS Electron spin-resonance spectroscopy was performed using the spin-trapping agent 5,5-dimethyl-1-pyrroline N-oxide (DMPO) for the detection of the(More)
Latanoprost is a prostaglandin analog widely used to lower intraocular pressure (IOP) in patients with glaucoma. Its reported mechanism for lowering intraocular pressure includes upregulation of matrix metalloproteinases (MMPs) in uveoscleral fl ow. Topical latanoprost is therefore also likely to affect the metabolism and gene expression of MMPs and the(More)
PURPOSE To investigate the effects of repeated treatments with a neuroprotective compound, R(-)-1-(benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol hydrochloride (T-588), on retinal ganglion cell (RGC) survival in rat eyes with elevated intraocular pressure (IOP) or after optic nerve crush. METHODS An increase in IOP was induced by a(More)
Multiagent-based simulations are a key part of several research fields. Multiagent-based simulations yield multiagent societies that well reproduce human societies, and so are seen as an excellent tool for analyzing the real world. A multiagent-based simulation allows crowd behavior to emerge through interactions among agents where each agent is affected by(More)
i 2 1 2 – 2 1. 1 ii 2. 2 OD 1. 1 2 2 MATSim-T MATSim-T 2. Abstract Agent-based simulation is recognized as a useful technology for understanding social systems and social phenomena. In order to make a social simulation have more realism, it is effective to assign a real human behavior to each agent which makes up the virtual society. In addition, it is(More)
  • 1