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The sense of taste is of critical importance to animal survival. Although studies of taste signal transduction mechanisms have provided detailed information regarding taste receptor calcium signaling molecules (TRCSMs, required for sweet/bitter/umami taste signal transduction), the ontogeny of taste cells is still largely unknown. We used a novel approach(More)
In response to low ambient temperature, mammalian cells as well as microorganisms change various physiological functions, but the molecular mechanisms underlying these adaptations are just beginning to be understood. We report here the isolation of a mouse cold-inducible RNA-binding protein (cirp) cDNA and investigation of its role in cold-stress response(More)
Background. Members of the Runx gene family encode transcription factors that bind to DNA in a sequence-specific manner. Among the three Runx proteins, Runx2 comprises 607 amino acid (aa) residues, is expressed in bone, and plays crucial roles in osteoblast differentiation and bone development. We examined whether the Runx2 gene is also expressed in testes.(More)
Target detection performance is known to be influenced by events in the previous trials. It has not been clear, however, whether this bias effect is due to the previous sensory stimulus, motor response, or decision. Also it remains open whether or not the previous trial effect emerges via the same mechanism as the effect of knowledge about the target(More)
Prof. Tanaka is charged with education of interdisciplinary medical informatics and bioinformatics. For undergraduate .He supervises 31 students of PhD course and 2 students in Master course in Graduate School of Medical and Dental Sciences and 6 students of PhD course and 12 students in Master course in Biomedical Science PhD Program. He is a principle(More)
The cellular role of protein kinases (PKs) have been studied extensively, but relatively little is known as to how specific expression of PKs mediate early development and differentiation. We have used directed differentiation of ES cells towards the mes-endodermal lineage in combination with microarray analysis to identify a set of PKs that are induced(More)