Yoshitsugu Inoue

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PURPOSE To evaluate the preventive effect of vaccination using fusion protein (gD-IL-2) consisting of herpes simplex virus type 1 (HSV-1) glycoprotein D (gD), and human interleukin-2 (IL-2), and plasmid DNA encoding gD-IL-2 against murine herpetic keratitis. METHODS Plasmid containing gD-IL-2 (pHDLneo1) was constructed, and gD-IL-2 peptide was purified.(More)
PURPOSE Traumatic optic neuropathy often induces a loss of vision that proceeds rapidly within several hours, together with retinal ganglion cell death, in a much slower time course. Electrical stimulation has previously been shown to rescue injured retinal ganglion cells from cell death. The present study tests whether transcorneal electrical stimulation(More)
PURPOSE To investigate the therapeutic effects of topical tacrolimus ointment on refractory ocular surface inflammatory diseases. DESIGN Retrospective interventional consecutive case series. PARTICIPANTS Ten consecutive patients with severe ocular surface inflammatory diseases who were suspected to be steroid responders (elevation of intraocular(More)
PURPOSE The purpose of the study was to investigate the recurrence-free interval after phototherapeutic keratectomy (PTK) in patients with corneal dystrophies resulting from an Arg124His (R124H) mutation of the Big-h3 gene. METHODS Patients with corneal dystrophy resulting from a genetically confirmed Big-h3 R124H mutation were examined with a slit lamp.(More)
To study variations of Epstein-Barr virus (EBV), we analyzed the gp350/220 gene for several cell lines and Japanese wild isolates using direct sequencing. The N-terminal region was highly conserved in all EBVs except for Jijoye/P3HR-1 and a few isolates. The variation of the region coincided with EBV types A and B (also referred to as types 1 and 2) and(More)
To compare disinfection by povidone-iodine (PI) solution with that by polyvinyl alcohol-iodine (PAI) solution in preoperative eyewash and to assess the optimal duration of the preoperative application of 0.5% levofloxacin (LVFX) ophthalmic solution. Two-hundred-seventy-two elderly cataract patients who had undergone phacoemulsification aspiration with(More)
PURPOSE To report endophthalmitis rates after cataract surgery and the incidence of complications after intracameral moxifloxacin injection. SETTING Nineteen clinics in Japanese institutions. DESIGN Retrospective survey cohort study. METHODS The number of surgeries and endophthalmitis cases in the past 4 years before and after the introduction of(More)
PURPOSE To determine the roles played by toll-like receptor 9 (TLR9) in cultured human corneal endothelial (HCEn) cells after herpes simplex virus type 1 (HSV-1) infection and to characterize the TLR9-mediated antiviral responses. METHOD Immortalized HCEn cells were examined for TLR expression. The upregulation of inflammatory cytokines after HSV-1(More)
Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and(More)
PURPOSE To evaluate the effectiveness of topical agents for the treatment of Acanthamoeba keratitis (AK). DESIGN Laboratory research. PARTICIPANTS Fifty-six Acanthamoeba isolates from 56 patients with clinically proven AK were studied. METHODS The effectiveness of 7 agents against Acanthamoeba cysts was determined in vitro. The agents were 1.0%(More)