Yoshito Kimura

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Crude synaptic membranes treated with Triton X-100 (TX) bound gamma-aminobutyric acid (GABA) to two classes of receptor site in Na+-free 10 mM-Tris-sulfate buffer (pH 7.4), but to only a single class of receptor site in 10 mM Tris-sulfate buffer (pH 7.4), containing 150 mM-NaCl. The high-affinity receptor site in TX membranes was specifically masked in the(More)
  • Y Kimura
  • 2000
Influenza A/WSN/33 virus inoculated into the olfactory bulb of C57BL/6 mice selectively infects the anterior olfactory nucleus, habenular, paraventricular thalamic, and brainstem monoaminergic neurons. Infected neurons died by day 12 with perforin-mediated neuroapoptosis, that appears significant to exterminate the intracellular pathogen in the early stage(More)
Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to liver cirrhosis. It is still unknown how only limited patients with fatty liver develop NASH. Tumor necrosis factor (TNF)-α is one of the key molecules in initiating the vicious circle of inflammations. Nardilysin (N-arginine dibasic(More)
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