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Emergence of Mycoplasma genitalium with clinically significant fluoroquinolone resistance conferred by amino acid changes both in GyrA and ParC in Japan.
We observed fluoroquinolone treatment failures in 2 men with Mycoplasma genitalium-positive non-gonococcal urethritis in Japan. A fluoroquinolone regimen of sitafloxacin 100 mg twice daily for 7 daysExpand
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Clinical effectiveness and safety of tazobactam/piperacillin 4.5 g for the prevention of febrile infectious complication after prostate biopsy.
We investigated the clinical effectiveness and safety of tazobactam/piperacillin (TAZ/PIPC) in a 1:8 ratio, a β-lactamase inhibitor with penicillin antibiotic, for the prevention of febrileExpand
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A compact intermediate state of calmodulin in the process of target binding.
Calmodulin undergoes characteristic conformational changes by binding Ca(2+), which allows it to bind to more than 300 target proteins and regulate numerous intracellular processes in all eukaryoticExpand
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An example of fault site localization on a 0.18 mum CMOS device with combination of front and backside techniques
Abstract This paper describes a failure analysis on a 0.18 μm CMOS device. To find out fault mechanism, combination of several fault localization techniques that are both front and backside wereExpand
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Non‐native α‐helix formation is not necessary for folding of lipocalin: Comparison of burst‐phase folding between tear lipocalin and β‐lactoglobulin
Tear lipocalin and β‐lactoglobulin are members of the lipocalin superfamily. They have similar tertiary structures but unusually low overall sequence similarity. Non‐native helical structures areExpand
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Helical and expanded conformation of equine beta-lactoglobulin in the cold-denatured state.
The thermal unfolding transition of equine beta-lactoglobulin (ELG) was investigated by circular dichroism (CD) over a temperature range of -15 degrees C to 85 degrees C. In the presence of 2 M urea,Expand
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Structural and thermodynamic consequences of removal of a conserved disulfide bond from equine β‐lactoglobulin
A disulfide bond between cysteine 66 and cysteine 160 of equine β‐lactoglobulin was removed by substituting cysteine residues with alanine. This disulfide bond is conserved across the lipocalinExpand
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Ferritin Assembly Revisited: A Time-Resolved Small-Angle X-ray Scattering Study.
The assembly reaction of Escherichia coli ferritin A (EcFtnA) was studied using time-resolved small-angle X-ray scattering (TR-SAXS). EcFtnA forms a cagelike structure that consists of 24 identicalExpand
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Relationship between chain collapse and secondary structure formation in a partially folded protein.
Chain collapse and secondary structure formation are frequently observed during the early stages of protein folding. Is the chain collapse brought about by interactions between secondary structureExpand
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Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene
Objective The molecular basis of neuroleptic malignant syndrome (NMS) is unclear, but clinical studies have noted a genetic predisposition. A recent genetic study suggested an association between NMSExpand
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