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Study on penetration of titanium dioxide (TiO(2)) nanoparticles into intact and damaged skin in vitro.
TLDR
Skin penetration of four different types of rutile titanium dioxide (TiO(2) was determined with in vitro intact, stripped, and hair-removed skin of Yucatan micropigs to study the effect of dispersion and skin conditions. Expand
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells.
TLDR
The results indicate that the observed trialkyltin-induced alterations in human choriocarcinoma cells are due to other mechanism in addition to a regulation of hCG and CYP19 mRNA levels, and the placenta represents a potential target organ for trialkyeltin compounds, whose endocrine-disrupting effects might be the result of local changes in h CG and estrogen concentrations in pregnant women. Expand
Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4.
TLDR
The results suggest that the 16 C-terminal amino acids of C-CPE are responsible for the interaction of C -CPE and claudin-4 following the disruption of TJ barrier function. Expand
Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone.
TLDR
A powder SD of indomethacin (IM) with CrosPVP was prepared using mechanical mixing followed by heating to temperatures below the melting point to produce IM in an amorphous state when its concentration was <40%. Expand
RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells
TLDR
The results suggested that the combination of fiber-modified Ad vectors containing polylysine peptides and RNAi is an effective tool for the study of the biological and physiological mechanism of adipogenesis in adiposity and diabetes using 3T3-L1 models. Expand
Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1
TLDR
This study contributes to an understanding of the biological mechanism in innate immune host responses and liver toxicity toward systemically administered Ad vectors and will help in designing safer gene therapy methods that can reduce robust innate immunity and inflammatory responses. Expand
Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR‐TBTs
TLDR
TR‐TBTs are an appropriate in vitro model for investigating carrier‐mediated transport functions at the blood–brain barrier (BPB) and the expression patterns of nucleoside and neurotransmitter transporters examined are quite similar in both the BPB and BBB. Expand
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity.
TLDR
The fiber knob mutation is optimized for further reduced in vivo transduction for further improving the mutant Ad vector, abolishing both viral natural tropism and toxicity. Expand
Nitric Oxide Donors Enhance Rectal Absorption of Macromolecules in Rabbits
TLDR
It is suggested that NO enhanced macromolecular absorption from the rectum without mucosal cell damage, and that NO donors can act as potent absorption enhancers. Expand
The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader.
A solid dispersion (SD) powder of indomethacin (IM) with CrosPVP was prepared continuously using a twin-screw extruder (extruder) or twin-screw kneader (kneader), which made it possible toExpand
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