Yoshitaka Uno

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RNA interference is a powerful tool for target-specific knockdown of gene expression. However, efficient and safe in vivo delivery of short interfering RNA (siRNA) to the target organ, which is essential for therapeutic applications, has not been established. In this study we used α-tocopherol (vitamin E), which has its own physiological transport pathway(More)
We originally reported the use of vitamin E (α-tocopherol) as an in vivo vector of short-interfering RNA (siRNA) to the liver. Here, we apply our strategy to the brain. By combining high-density lipoprotein (HDL) as a second carrier with α-tocopherol-conjugated siRNA (Toc-siRNA) in the brain, we achieved dramatic improvement of siRNA delivery to neurons.(More)
Energy efficiency improvements of renovated district heating and cooling (DHC) plants were evaluated by simulation. In this paper, the simulation models for the original and renovated plants are developed based on the equipment specifications of the original plant. Accuracy of this model is examined based on the comparison of the measurement data from the(More)
A 22-year-old woman presented to us with seizures of a few minutes duration. She had clinical features of Albright hereditary osteodystrophy (AHO), including hypocalcemia, hyperphosphatemia and resistance to parathyroid hormone. Genetic testing revealed a sporadic form of pseudohypoparathyroidism type Ib (PHP-Ib). This is the first Japanese case involving(More)
District heating and cooling (DHC) systems show a great potential to save energy. However, DHC has a number of problems related to other systems within a building; for example, decrease in the temperature difference between the supply and return water carrying cooling and heating energy affects efficiency. The main reason is that the DHC plant and the(More)
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