Yoshitaka Hasegawa

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Topographical projections from the thalamus, subthalamic nucleus (STN) and pedunculopontine tegmental nucleus (PPN) to the striatum were examined in the Japanese monkey (Macaca fuscata) by using the retrograde axonal transport technique of WGA-HRP (wheat germ agglutinin-conjugated horseradish peroxidase). After WGA-HRP injection in the head of the caudate(More)
The special areal and laminar distributions of cortical afferent connections from various thalamic nuclei in the monkey (Macaca fuscata) were studied by using the anterograde axonal transport technique of autoradiography. The following findings were obtained. The superficial thalamocortical (T-C) projections, terminating in the (superficial half of)(More)
Our findings revealed the nucleus ventralis lateralis pars oralis (VLo) projection to motor area, and the nucleus ventralis anterior pars principalis (VApc) projections to the premotor and supplementary motor areas (SMA). The VLo gave rise to thalamocortical projections terminating in the superficial half of layer I, mainly in the forelimb motor area. The(More)
The alpha 1-adrenoceptor subtypes in ventral and dorsal horns of rat lumbar spinal cord were studied. High concentrations of the alpha 1D-adrenoceptor antagonist, BMY 7378 (8-[2-[4-(2-methoxyphenyl) 1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride), displaced bound [3H]prazosin in a single-site manner and the binding affinity was close(More)
The topographical organization of the projections from the cerebral cortex to the head of the caudate nucleus was studied in the cat using the horseradish peroxidase method. Various amounts of horseradish peroxidase were injected into several sites of the head portion of the caudate nucleus at about the frontal level where its cross section was widest.(More)
After horseradish peroxidase (HRP) injections into various parts of the ventral thalamic nuclear group and its adjacent areas, the distribution of labeled neurons was compared in the cerebral cortex, basal ganglia, and the brain stem. The major differences in distribution patterns were as follows: Injections of HRP into the lateral or ventrolateral portions(More)
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions (in healthy states), which remains largely unknown. We showed endogenous/basal expression of activin in(More)
We investigated rapid protection effect by estradiol on corticosterone (CORT)-induced suppression of synaptic transmission. Rapid suppression by 1 μM CORT of long-term potentiation (LTP) at CA3-CA1 synapses was abolished via coperfusion of 1 nM estradiol. N-methyl-D-aspartate (NMDA) receptor-derived field excitatory postsynaptic potential (NMDA-R-fEPSP) was(More)
The spinofacial projection was revealed using anterograde transport of radioactively labeled protein in the monkey. The projection arises from cells in the lateral part of the spinal dorsal horn (i.e. the lateral part of lamina V of Rexed) at the upper cervical cord, mainly C1 segment, ascends in the medial or ventromedial part of the anterior funiculus(More)
The subtypes of alpha1-adrenoceptor mediating facilitation of alpha-motoneuron activity in adult rat spinal cord were examined. The potencies of agonists and antagonists were compared, using extracellular single unit recordings made in spinal cord slices isolated from adult rats. Catecholamines (epinephrine, norepinephrine), phenylethylamines(More)