Yoshitada Yajima

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In order to clarify the involvement of oxygen radicals in lung carcinogenesis induced by diesel exhaust particles (DEP), the relationship between lung tumour response and formation of 8-hydroxydeoxyguanosine (8-OHdG) in lung DNA was examined. The role of high dietary fat and beta-carotene on these responses was also studied. Mice were intratracheally(More)
The effectiveness of combined administration of Ftorafur (FT) and Krestin (PSK) on experimentally-induced liver cancer has not been established. This study was undertaken to elucidate the effect of combined administration of these drugs on tumor growth and temporal changes in the immuno-endocrine system under this immunochemotherapy. Male inbred WKA/H(More)
The aim of the study was to determine the transition rate and factors associated with the progression of normo- and low microalbuminuria to diabetic nephropathy (overt proteinuria). For 8 years we prospectively observed 1,558 Japanese patients with type 2 diabetes mellitus whose basal urinary albumin:creatinine ratio (UACR) had been measured as <17.0(More)
UNLABELLED Caucasian type 2 diabetic patients with microalbuminuria (MA) or overt nephropathy (ON) show greater heterogeneity of renal lesions than type 1 diabetic patients. We examined whether a similar situation exists in 30 Japanese type 2 diabetic patients [21 male, age 48 +/- (SD) 8 years, known duration 11 +/- (SD) 8 years] without definable renal(More)
We relieved several side effects by modifying chemotherapy and concurrently using biological response modifiers (BRMs) to experimentally and clinically investigate treatment, which can maintain quality of life (QOL) for lung cancer patients including changes in systemic immune capacity. sIL-2R levels are useful for predicting the course after recurrence.(More)
Using sIL-2R and IAP values as indices, we examined the effect of administering BRMs to relieve bone marrow suppression and immunosuppression associated with modified VP therapy (CBDCA + VP-16) in patients with lung cancer. G-CSF significantly improved leukopenia. PSK inhibited decreases in the leukocyte count, although the action of PSK was weaker than(More)
In this study we investigated the effect of combined administration of UFT and Krestin (PSK) on the growth of intraperitoneal metastasis and temporal changes in the immune-endocrine system under this immunochemotherapy. At 7 days, Plasma ACTH levels of the PSK group were significantly lower than that of the control group (p<0.01). At 14 days, the tumor(More)
It is said that stable strontium (Sr), which exists naturally in living cells as a microelement, has cytoprotective effects on liver cells in mammals. We attempted to examine the cytoprotective and anticancer effects of Sr using the rat carcinogenetic model induced by DMH (1,2-dimethylhydrazine). In a comparison of animals given UFT, PSK and Sr or UFT and(More)
The three-dimensional ultrastructure of the glomerular basement membrane (GBM) and mesangial matrix (MM) in streptozotocin (STZ)-induced diabetic rats and in one case of a human diabetic nephropathy were examined using the quick-freezing and deep-etching method. In the diabetic rats, the GBM inner layer was diffusely enlarged, and the meshwork structures in(More)
The three-dimensional ultrastructure of glomerular basement membrane (GBM) and mesangial matrix (MM) at an early stage of streptozotocin (STZ)-induced diabetes mellitus in rats was examined by the quick-freezing and deep-etching method. In diabetic rats, the GBM inner layer was diffusely enlarged and the meshwork structure not only in the GBM middle layer(More)