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Hematopoietic stem and progenitor cells (HSPC), attracted by the chemokine CXCL12, reside in specific niches in the bone marrow (BM). HSPC migration out of the BM is a critical process that underlies modern clinical stem cell transplantation. Here we demonstrate that enforced HSPC egress from BM niches depends critically on the nervous system. UDP-galactose(More)
The selectin family of adhesion molecules and their glycoconjugated ligands are essential for blood polymorphonuclear neutrophil (PMN) extravasation into inflammatory and infectious sites. However, E-selectin ligands on PMNs are not well characterized. We show here that CD44 immunopurified from G-CSF-differentiated 32D cells or from peripheral blood PMNs(More)
30 31 32 2 SUMMARY 1 The bone marrow (BM) niche comprises multiple cell types which regulate 2 hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the 3 circulation. Here, we demonstrate that osteocytes, the major cellular component of 4 mature bone, are regulators of HSPC egress. Granulocyte colony-stimulating factor 5 (G-CSF),(More)
Hematopoietic stem/progenitor cells (HSPCs) are released from the bone marrow to the circulation by the cytokine, granulocyte colony-stimulating factor, via sympathetic nervous system (SNS)-mediated osteoblast suppression. Because the orientation of HSPCs in their osteoblastic niche is reported to be guided by [Ca(2+)], we speculated on a cooperation(More)
An image sensor in which each pixel has a processing element is called a vision chip. The vision chip can perform real-time visual processing at a high frame rate of 1000 fps, and is expected to find application to intelligent robots and electronic devices. The vision chip has a different structure from existing processors and required special programming(More)
Vesnarinone, a phosphodiesterase inhibitor, prolongs cardiac action potential duration by inhibiting the delayed rectifier K(+) current, I(K). We examined the effect of this agent on human ether-a-go-go related gene (HERG) and KvLQT1/minK K(+) channels heterologously expressed in human embryonic kidney 293T cells with the whole-cell patch-clamp technique.(More)
Posttranscriptional machinery regulates inflammation and is associated with autoimmunity as well as tumorigenesis in collaboration with transcription factors. We previously identified the tumor suppressor gene transformed follicular lymphoma (TFL) on 6q25 in a patient with follicular lymphoma, which transformed into diffuse large B cell lymphoma. TFL(More)
Hematopoietic stem/progenitor cells (HSPCs) are released from the bone marrow to the circulation by the cyto-kine, granulocyte colony-stimulating factor, via sympathetic nervous system (SNS)–mediated osteoblast suppression. Because the orientation of HSPCs in their osteoblastic niche is reported to be guided by [Ca 2؉ ], we speculated on a cooperation(More)
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