Yoshinori Minami

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Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression(More)
Histamine H1 antagonists rarely cause drug-induced lung injury (DLI). A woman in her 60s, who had been taking antihistaminic levocetirizine for 2 months, presented with progressive cough and shortness of breath. A chest radiograph showed patchy infiltrations on both lower lung fields. Chest computed tomography findings were consistent with non-specific(More)
The antitumor antibiotic C-1027, an acidic protein with a molecular weight of 15,000, was isolated from the culture filtrate of Streptomyces globisporus C-1027. Its physico-chemical and biological properties have been reported pre-viously1'^. This antibiotic was found to consist of two components, a protein and a very labile non-protein(More)
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