Yoshimichi Miyazaki

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BACKGROUND There is a growing body of evidence demonstrating that deep brain stimulation (DBS) of globus pallidus internus (GPi DBS) and subthalamic nucleus (STN DBS) are effective treatment for patients with Parkinson's disease (PD). However, it remains controversial whether the best stimulation target for a PD patient is GPi or STN. METHODS A computer(More)
Progressive myoclonic ataxia (PMA) is a clinical syndrome defined as progressive ataxia and myoclonus and infrequent seizures in the absence of progressive dementia. Due to the extremely heterogeneous nature of PMA, a large proportion of PMA cases remain molecularly undiagnosed. The aim of this study was to clarify the molecular etiology of PMA. The patient(More)
There are many tools for differentiating between multiple system atrophy with predominant parkinsonian features (MSA-P) and Parkinson's disease (PD). These include middle cerebellar peduncle (MCP) width, apparent diffusion coefficient (ADC) value of the putamen and cerebellum, and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy images. We(More)
Although there are some newly developed options to treat dystonia, its medical treatment is not always satisfactory. Zolpidem, an imidazopyridine agonist with a high affinity on benzodiazepine subtype receptor BZ1 (ω1), was found to improve clinical symptoms of dystonia in a limited number of case reports. To investigate what subtype of dystonia is(More)
OBJECTIVE Cramp-fasciculation syndrome (CFS) is a heterogeneous condition with multiple underlying causes. Although dysfunction of slow K(+) channels has been reported in patients with CFS, testing all potential candidates for this problem using conventional in vitro functional analysis would be prohibitively cost- and labor-intensive. However, relatively(More)
Background: Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been accepted as one of the most useful methods for the diagnosis of Parkinson’s disease (PD). Moreover, the accumulated evidence has indicated that the heart-to-mediastinum (H/M) ratio correlates with the disease severity of hypokinesia/ bradykinesia and rigidity. The(More)
A case of cryptococcal meningitis that developed in a healthy subject is reported. The patient received a three-drug therapy using Liposomal amphotericin-B, fulcytosine, and Voriconazole, and a good effect of the treatment was observed. Cryptococcal meningitis is often aggravated, and early diagnosis and the long-term continuation of treatment are important.
Identification of causative genes for hereditary dystonia and elucidation of their functions are crucial for better understanding of dystonia pathogenesis. As seen in other hereditary neurologic disorders, intra- and inter-familial clinical variations have been demonstrated in hereditary dystonia. Asymptomatic carriers can be found due to alterations in(More)
The updated meta-analysis demonstrated that neurostimulation for treating Parkinson’s disease (PD) resulted in more improvement in quality of life compared with medication alone [1]. However, the target of deep brain stimulation has been a controversial matter. In this context, we performed a meta-analysis of pallidal and subthalamic stimulation for PD, and(More)