Yoshimasa Niwa

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BACKGROUND Surveyor nuclease is a new single-strand-specific endonuclease that cleaves heteroduplex DNA at a base-mismatch site in both DNA strands. We applied this enzyme to detection of p53 gene mutations in haematological malignancy. METHODS DNA fragments including exons 5 and 6, and those including exons 7 and 8, of the p53 gene, were amplified by(More)
This paper describes the "xtel" development environment for "Ubiquitous Content". Ubiquitous contents are real space applications that are embedded in day-to-day life and intended for use by consumers. This is content that is experienced through interaction with people, objects and environments that exist in real space. Xtel comprises three tools: the(More)
Idiopathic renal hypouricemia is a hereditary disease characterized by abnormally increased renal excretion of urate. This disorder is primarily caused by a mutation of the SLC22A12 gene encoding human urate transporter 1 (URAT1). We recently encountered a case of severe hypouricemia (urate level: 0.5mg/dl in serum, 1.19g/l in urine), which was discovered(More)
Talktic is a platform for the easy production of entertainment content developed under the keyword of "pervasive computing." The Talktic platform consists of runtime environment, library, and development environment to support applications using an MCU board, personal computer, and network. It uses a virtual machine in the runtime environment and provides a(More)
Microscopic morphological findings in smeared and stained blood cells are difficult to be characterized quantitatively. However, a recent progress in digital image processing has been enabled to express some of these findings quantitatively. In this report, we propose the usefulness to determine "box" fractal dimension of nuclear image of lymphocyte.(More)
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