Yoshimasa Kadooka

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Recent advances in biotechnology and the availability of ever more powerful computers have led to the formulation of increasingly complex models at all levels of biology. One of the main aims of systems biology is to couple these together to produce integrated models across multiple spatial scales and physical processes. In this review, we formulate a(More)
To understand the macroscopic function of the human heart based on sub-cellular microscopic events, multiscale analysis is indispensable. Our heart simulator uses the so-called homogenization method, where both the human heart and the myocardial cells are modeled and solved simultaneously by the finite element method. Because the contraction and deformation(More)
BACKGROUND Recent studies, supported by advances in computer science, have successfully simulated the excitation and repolarization processes of the heart, based on detailed cell models of electrophysiology and implemented with realistic morphology. METHODS In this study, we extend these approaches to simulate the body surface electrocardiogram (ECG) of(More)
Recently, there have been demands for greater functional diversity and higher performance in the information technology infrastructure. As a result, the complexity and scale of product design in the product development phase have increased. In addition, development periods need to be reduced so products can be marketed sooner. These requirements have(More)
BACKGROUND The currently proposed criteria for identifying patients who would benefit from cardiac resynchronization therapy (CRT) still need to be optimized. A multi-scale heart simulation capable of reproducing the electrophysiology and mechanics of a beating heart may help resolve this problem. The objective of this retrospective study was to test the(More)
Desk Side Laboratory (DSLab), which allows scientists and engineers in geographically different locations to do state-of-the-art research and development through Internet on their Web browsers, has been developed only using commodity products. It has an easy-to-use user interface. It has been found that, when applied to an optimization design of mobile(More)
With evolution of PIV experimental technologies, the needs for high performance computer resources, large scale storage system and advanced visualization engine are getting higher. However, it would be a severe burden for the researchers to prepare such high performance, large scale, and advanced resources by themselves. On the other hand, the necessity of(More)