Yoshiko Terada

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PURPOSE To develop a model of verteporfin photodynamic therapy (PDT) for experimental choroidal neovascularization CNV in the rat. METHODS A laser injury model was used to induce experimental CNV in rats. The transit and accumulation of the photosensitizer verteporfin was assessed angiographically in CNV lesions, to determine the optimal time for delivery(More)
OBJECTIVE To evaluate the feasibility, efficacy, and selectivity of photodynamic therapy (PDT) using targeted delivery of verteporfin to choroidal neovascularization (CNV) in the rat laser-injury model of CNV. METHODS We performed PDT in rat eyes on experimental CNV and normal retina and choroid using verteporfin conjugates. A targeted verteporfin(More)
A collaborative study was conducted by 30 laboratories that participated in the Behavioral Teratology Meeting in Japan. Pregnant Sprague-Dawley rats from four breeders were orally administrated 200 mg/kg of phenytoin each day from day 10 to day 14 of gestation. The offspring were tested for behavioral teratogenic effects at various ages. The effects were(More)
The post-tetanic hyperpolarizations (PTHPs) were recorded from the isolated bullfrog sciatic nerves using a modified vaseline gap method. Repetitive stimulation of tetrodotoxin-resistant (TTX-R) C-fibers produced frequency- and activity-dependent PTHPs. The ouabain solutions (0.1 mM), the solutions (0.1 mM ouabain + 2 mM tetraethylammonium (TEA)) and 5 mM(More)
The present study was carried out to examine the properties of A and C fibers in the bullfrog sciatic nerves by applying several agents through perfusing solutions between stimulating and recording electrodes. The compound action potentials (CAPs) of A beta and A delta fibers were tetrodotoxin (TTX)-sensitive and were abolished in Na(+)-free solution.(More)
The post-tetanic hyperpolarizations (PTHPs) of the fast and slow tetrodotoxin-resistant (TTX-R) C-fibers were recorded from isolated bullfrog sciatic nerves using a modified vaseline gap method. Under control solutions, the monophasic fast and slow TTX-R C-fibers compound action potentials (C-CAPs) increased in amplitude up to 133.9+/-17.9% (mean+/-SD; n =(More)
It has been shown that a test capsule originally designed as a simple and reliable aid to evaluate masticatory ability could help to identify the characteristics of chewing loops between individuals in evaluation of masticatory movement, and detect even a slight disorder in the stomatognathic system. In this study, the Sirognathograph(R) Analysing System(More)
The C fiber compound action potentials (C-CAPs) were studied for their properties with the vaseline gap method from the isolated bullfrog sciatic nerve. Two components (the fast and the slow C-CAPs) were found to be Na+ dependent and tetrodotoxin-resistant. The conduction velocities of the fast and the slow C-CAPs were 0.61 +/- 0.06 m/s (n = 13) and 0.42(More)
The sagittal incisal jaw movement during swallowing saliva was measured on 11 subjects (range: 24-30 years old) with "normal occlusion" by using a two-dimensional system applied infrared sensor. The duration of swallowing saliva and that of tooth contact were calculated with the program developed in our laboratory. The results obtained were as follows: 1.(More)
The metals for porcelain fusing used in this study were gold alloys and nickel-chromium alloys. Chromatic characteristics were compared between samples of 0.1, 0.2 and 0.3 mm thickness. The dentin porcelain was fused on the opaque surface. Chromatic analyses were then carried out at each stage of 0.1 mm-incremental reductions of the dentin thickness(More)