Yoshiki Tani

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INTRODUCTION Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated the efficacy of bevacizumab, an antibody against vascular endothelial growth factor and an inhibitor of angiogenesis, in the treatment of OA using a rabbit model of anterior cruciate ligament transection. METHODS First, we evaluated the response of(More)
BACKGROUND T2 mapping is an MRI method particularly reflective of the collagen arrangement in the cartilage, and diffusion tensor (DT) imaging captures the diffusion of water molecules. Laser-induced photoacoustic measurement (LIPA) makes it possible to assess not only the thickness of the cartilage layer but also its viscoelastic properties. By assessing(More)
Fructosyl-amino acid oxidase (FAOD)-reactive fraction (FRY) was found in commercial yeast extract. FRY showed very hydrophilic property and was adsorbed to phenylboronate silica gel, indicating that it contained the Amadori compound. TLC and amino acid analyses revealed that glucosone, lysine, and arginine were produced from FRY after incubation with FAOD.(More)
Neuronal spike trains are regarded as stochastic point processes. To estimate the order and the vale of Markov properties of the adjacent interspike interval sequences, we have proposed new statistics "dependency" Dm for discrete variable and "simplified dependency" Dm for continuous variable in the stationary point processes, and Dm(t) for discrete(More)
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