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Twenty-one healthy, susceptible adult male volunteers were enrolled in a double-blind study designed for evaluation of the prophylactic efficacy of ascorbic acid (3 g daily) in induced rhinovirus 44 infection of the upper respiratory tract. While in continuous isolation, 11 men received 1 g of ascorbic acid three times daily, and 10 men received a placebo… (More)
The comparative prophylactic effectiveness of oral treatment with ribavirin (1-beta-D-ribofuranosyl-1,2,4,triazole-3-carboxamide; virazole) and amantadine hydrochloride against artificially induced infection with influenza A virus was evaluated in 29 seronegative men who received ribavirin capsules (200 mg) three times daily, placebo capsules three times… (More)
Volunteers inoculated nasopharyngeally with liver A2/AA/6/60 virus grown in primary bovine kidney cell cultures at 25 C were asymptomatic but developed significant serum and respiratory secretory antibody responses. Viruses were not recovered from these volunteers who had a low or moderate level of prevaccination antibody titers.
The prophylactic effectiveness of oral administration of ribavirin (1-beta-D-ribofuranosyl-1,24-triazole-3-carboxamide, virazole) against artificially induced influenza B infection was evaluated in a double-blind clinical trial. Fifteen seronegative men received ribavirin capsules (600 mg/day in three divided doses), and 15 other men received placebo… (More)