Yoshikazu Shimomura

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We studied the distributions of four different cyclic AMP-specific phosphodiesterase isoform mRNAs (APDE1-4) and compared them with that of 63 kDa calmodulin-stimulated phosphodiesterase (CPDE) in the rat brain by in situ hybridization histochemistry using specific radiolabeled oligonucleotides. The distribution patterns were unique for all the APDE(More)
PURPOSE To quantify the degree of metamorphopsia in patients with idiopathic epiretinal membranes (ERMs), by use of a new metamorphopsia chart (M-CHARTS) developed by the authors. METHODS These M-CHARTS had 19 dotted lines with dot intervals of between 0.2 degrees (fine) and 2.0 degrees (coarse) visual angles. As the dot intervals were changed from fine(More)
PURPOSE The aim of this study was to investigate the expression changes of epithelial mesenchymal transition (EMT)-related molecules induced by TGF-β signaling in a human corneal epithelial cell line (HCECs). METHODS The cellular response to TGF-β was evaluated by immunoblotting, quantitative real-time RT-PCR, and immunofluorescence microscopy in HCECs.(More)
PURPOSE To analyze the relationship between corneal topography and letter contrast sensitivity. METHOD Experiments were conducted on 59 eyes of 51 patients who had best spectacle-corrected visual acuity of 20/20 or better and no ocular pathology except for the corneal shape. Thirty-nine eyes had an abnormal topographic pattern resulting from keratoconus,(More)
To assess how target size and eccentricity affect binocular summation (BS) of reaction time (RT) at suprathreshold level, we measured RT using targets of 0.108° and 0.216° at four eccentricities (0°, 5°, 15°, 25°) in six normal volunteers. The difference between the monocular/binocular RT differentials for both sizes significantly increased in the periphery(More)
PURPOSE To investigate the effect of thresholds on binocular summation for detection and resolution of parallel-line targets of different widths. METHODS The automatic perimeter Octopus 201 (Haag-Streit International, Köniz, Switzerland) combined with a modified haploscope device and targets consisting of parallel lines that were 10' (10' target), 2.5'(More)
BACKGROUND Visual information projected onto corresponding points on the right and left retinas converges on the binocular cells in the visual cortex. The aim of this study is to investigative the characteristics of the receptive field for binocular stimulation in the central visual field of normal-sighted human subjects. METHODS We investigated the(More)
PURPOSE To compare the detectability between glaucomatous visual field changes using standard automated perimetry (SAP), frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), and flicker perimetry and structural changes using optical coherence tomography (OCT). PARTICIPANTS Fifty-nine eyes of fifty-nine patients with open-angle(More)
PURPOSE The involvement of the epithelial mesenchymal transition (EMT) in the process of corneal wound healing remains largely unclear. The purpose of the present study was to gain insight into Slug expression and corneal wound healing. METHODS Slug expression during wound healing in the murine cornea was evaluated using fluorescence staining in vivo.(More)
PURPOSE To evaluate the outcomes of intravitreal injection of bevacizumab (IVB) for retinopathy of prematurity (ROP). METHODS IVB was selected to be the first treatment for type 1 ROP in 8 eyes (4 patients). Bevacizumab (0.25 mg/eye) was injected into the vitreous cavity under either general anesthesia or sedation. Fundus photography and fluorescein(More)