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Development of a safe method to increase brain-derived neurotrophic factor (BDNF) in the brain is expected to have utility in enhancing learning and memory, in protecting the brain, and in suppressing appetite. We investigated the effects of whole-body exposure to high voltage electric potential (HELP), which generates an electric field and current density(More)
Preconditioning the rat brain with spreading depression for 48 h induces potent ischemic tolerance (infarct tolerance) after an interval of 12-15 days, consequently reducing the infarcted lesion size in the acute phase following focal cerebral ischemia. However, persistence of the morphological and functional neuroprotection has not yet been proven. We(More)
BACKGROUND AND PURPOSE Status epilepticus and cerebral ischemia stimulate persistent neurogenesis in the adult brain, but both conditions cause neuronal damage. We determined whether spreading depression, a common epiphenomenon of these conditions, stimulates persistent neurogenesis. METHODS We analyzed the effect of KCl-induced spreading depression on(More)
Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to learning and memory in the mature brain. Here, we investigated the role of increased levels of intracerebral BDNF in learning(More)
Feeding-related neuronal activity of monkey amygdalar glucose-sensitive and morphine-sensitive cells was investigated during a task that required bar-pressing to obtain food. Both glucose-sensitive and morphine-sensitive cells, located mostly in the centromedial part of the amygdala, decreased firing during the bar-press period more often than insensitive(More)
BACKGROUND AND PURPOSE New immature neurons appear out of the germinative zone, in cortical Layers V to VI, after induced spreading depression in the adult rat brain. Because neural progenitors have been isolated in the cortex, we set out to determine whether a subgroup of mature cells in the adult cortex has the potential to divide and generate neural(More)
To investigate neuronal responses to interoceptive information, single neuron activity of the orbitofrontal cortex (OBF) of the behaving monkey was recorded during glucose injection, natural feeding and an operant bar press feeding task. Intravenous glucose injection had almost no effect on rates of spontaneous firing, but tended to attenuate neuronal(More)
Neuronal activity was studied in the behaving active monkey to elucidate the functional significance of catecholamines (CA) in the amygdala during reward-related behavior, and the effects of noradrenaline (NA), dopamine (DA), and their antagonists, electrophoretically applied, were examined using multibarreled electrode techniques. The operant food intake(More)
Single neuron activity in the monkey amygdala was investigated during cue signalled conditioned bar press feeding behavior and the effects of electrophoretically applied acetylcholine (ACh) and atropine were analyzed. ACh increased the firing rate of one third of the neurons tested; these excitatory responses were inhibited by the muscarinic receptor(More)
Long term, single neuron activity was recorded in the monkey orbitofrontal cortex (OBF) through chronic platinum-iridium microwire electrodes. Tonic as well as phasic changes in neuronal activity occurred upon presentation of palatable (food) and aversive stimuli during bar pressing for food. Lesions in this region are known to induce changes in emotional(More)