Yoshikazu Ikuta

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A basic experiment of peripheral nerve regeneration using neuronal progenitor cells embedded in collagen gel was performed in a rat sciatic nerve defect. First, when neuronal progenitor cells derived from the fetal rat hippocampus were cultured in atelocollagen-containing medium, neurospheres positive for anti-nestin antibody were confirmed after 8 days.(More)
Findings in 34 patients with traumatic brachial plexus injury documented by surgical exploration and intra-operative somatosensory-evoked potentials were correlated with findings on myelography and magnetic resonance imaging (MRI) to determine whether MRI can identify nerve root avulsion. The coronal and sagittal planes were not able to demonstrate avulsion(More)
We examined whether or not the cervical dorsal root ganglion (DRG) of the rat, when isografted and connected to the distal stump of the severed common peroneal nerve, could survive, project axons to the denervated leg muscles, and exert beneficial influences to delay the degeneration of the denervated muscles. Rats in which the muscles were similarly(More)
BACKGROUND As the immature spinal cord was nerve growth permissive, we examined glial reactions that influence regeneration of the spinal cord in a fetal rat spinal cord injury model. METHODS Three, 7, 21, and 35 days after intrauterine surgery, offspring were killed and the thoracic and lumbar spinal cords were carefully removed from the spinal column(More)
A non-protein extract isolated from the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin, NTP), has been clinically used in Japan for the treatment of chronic painful conditions such as low back pain, osteoarthritis, postherpetic neuralgia, subacute myelo-opticoneuropathy, and so on. Recent studies have shown its efficacy on patients(More)
Using 35 Japanese white rabbits, a study was made of tissue regeneration and the mechanical properties of the patellar tendon after removal of its central one-third. After removal of the central one-third of the patellar tendon on one side, in experiment 1 the strength of the entire patellar tendon including the regenerated tissue was compared with that of(More)
1. The effects of a new neurotrophic pyrimidine derivative of MS-430 on nerve regeneration was examined using Wistar rats whose left sciatic nerve had been subjected to controlled injury. 2. The functional recovery and the packing density of common peroneal nerve axons were significantly enhanced with the administration of 3 mg/kg/day of MS-430. 3. These(More)
The influence of a volume of a distal nerve segment upon nerve regeneration in an 8-mm gap created within a silicone tube was examined. The rats were randomly divided into four groups. Each group had 5 mm, 1 mm, or a half volume of 1-mm nerve segment (a nerve piece of 1 mm transected longitudinally) inserted into the distal end of a silicone tube of 11 mm.(More)
We used predegenerated acellular grafts to bridge proximal and distal stumps of transected nerves and studied how the duration of predegeneration might affect axonal regeneration. Predegenerated acellular grafts were prepared by transecting the tibial nerve of donor rats and, after a period of degeneration, freeze-thawing a 40-mm long segment of the distal(More)
We strongly believe that rotational transfer of a musculocutaneous island flap composed of the flexor digitorum brevis muscle is the best procedure currently available for covering and reconstructing the weight-bearing area of the heel and its posterior area from the histologic and functional points of view. Further, since it requires only one operation, we(More)