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Mitochondrial genome variation in eastern Asia and the peopling of Japan.
TLDR
Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period. Expand
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
TLDR
A fluorescence- or colorimetry-based allele-specific DNA-primer–probe assay system was used to determine the genotypes of 112 polymorphisms of 71 candidate genes in 2819 unrelated Japanese patients with myocardial infarction and 2242 unrelated Japanese controls. Expand
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
TLDR
Determination of the genotypes of the connexin 37, plasminogen-activator inhibitor type 1, and stromelysin-1 genes may prove reliable in predicting the genetic risk of myocardial infarction and might thus contribute to the primary prevention of this condition. Expand
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.
TLDR
Multivariate logistic-regression analysis with adjustment for age and sex revealed that the mitochondrial haplogroup N9a was significantly associated with resistance against type 2 diabetes mellitus (T2DM), suggesting that even in the modern environment, which is often characterized by satiety and physical inactivity, this haplogroups might confer resistance against T2DM. Expand
Association of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese women
TLDR
The results suggest that the estrogen receptor α gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women. Expand
Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men.
TLDR
The present results implicate the osteoprotegerin gene as a susceptibility locus for reduced BMD in Japanese women and were not associated with the 950T --> C or 245T --> G genotypes in men. Expand
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
TLDR
A meta-analysis of unpublished datasets suggests that an increase in homocysteine levels is not likely to result in a increase in risk of coronary heart disease. Expand
Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to
TLDR
The results suggest that the C–509→T polymorphism, alone or in combination with the T869→C polymorphisms, of the transforming growth factor-β1 gene is a genetic determinant of bone mass, and that the number of T alleles in the combined genotype is a risk factor for the genetic susceptibility to osteoporosis in postmenopausal Japanese women. Expand
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
TLDR
It is demonstrated that mitochondria targeted by the SmaI enzyme showed specific elimination of the mutant mtDNA, resulting in restoration of both the normal intracellular ATP level and normal mitochondrial membrane potential. Expand
Genetic Risk for Ischemic and Hemorrhagic Stroke
TLDR
The IL6 genotype may be useful in assessing the genetic risk for atherothrombotic cerebral infarction and intracerebral hemorrhage, and genotypes for UCP3, TNF, and PKD1-like may be similarly beneficial in assessment of the risk for subarachnoid hemorrhage. Expand
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