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Mitochondrial genome variation in eastern Asia and the peopling of Japan.
To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed usExpand
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
Background Although epidemiologic studies have suggested that several genetic variants increase the risk of myocardial infarction, large-scale association studies that examine many polymorphismsExpand
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
BACKGROUND Although epidemiologic studies have suggested that several genetic variants increase the risk of myocardial infarction, large-scale association studies that examine many polymorphismsExpand
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.
Because mitochondria play pivotal roles in both insulin secretion from the pancreatic beta cells and insulin resistance of skeletal muscles, we performed a large-scale association study to identifyExpand
Association of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese women
The estrogen receptor α gene is a candidate locus for genetic influence on bone mass. The possible association between two polymorphisms in the first intron of this gene, alone or in combination, andExpand
Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men.
Given that osteoprotegerin plays an important role in bone remodeling, the osteoprotegerin gene may be a candidate locus for susceptibility to osteoporosis. The relation of polymorphisms in theExpand
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
Robert Clarke and colleagues conduct a meta-analysis of unpublished datasets to examine the causal relationship between elevation of homocysteine levels in the blood and the risk of coronary heartExpand
Genetic Risk for Ischemic and Hemorrhagic Stroke
Objective—We performed an association study to identify gene polymorphisms for assessing the genetic risk of ischemic or hemorrhagic stroke. Methods and Results—The study population comprised 3151Expand
Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to
Transforming growth factor-β1 is an important local regulator of bone metabolism, acting downstream of estrogen and cooperatively with vitamin D. The possible association of a C–509→T polymorphism inExpand
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
The restriction endonuclease SmaI has been used for the diagnosis of neurogenic muscle weakness, ataxia and retinitis pigmentosa disease or Leigh's disease, caused by the Mt8993T-->G mutation whichExpand
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