Yoshihisa Mimura

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A suicide gene therapy using herpes simplex virus thymidine kinase (HSV-TK) with ganciclovir (GCV) has been under development as a tumor-targeted therapy; however, the mechanism of cellular GCV uptake, which is prerequisite in the therapy, has not been clarified. In an attempt to resolve this situation and gain information to optimize HSV-TK/GCV system for(More)
Atenolol, a β1-adrenergic receptor blocker, is administered orally and its intestinal absorption has recently been indicated to be mediated by carrier protein and reduced markedly by ingestion of some fruit juices, such as apple and orange juices. This could be postulated to be a problem arising from the interaction of some components of fruit juices with(More)
OVERVIEW: The leading medium in visual presentations at exhibitions and shows is fast becoming plasma displays. These displays feature full-color, 40-inch and larger screens having a thickness of only 10 centimeters or so, plus a wide viewing angle. They are unaffected by terrestrial magnetism and can be easily attached to walls or hung from ceilings. As a(More)
The intestinal absorption of atenolol has recently been reported to be reduced by simultaneous ingestion of fruit juices, such as apple juice. This finding implies a possibility that an unidentified carrier-mediated transport system, which could be interfered by some components of those juices, might be involved in atenolol absorption. In an attempt to(More)
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