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Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines
TLDR
Results indicate that both neuronal-type Nc and Ms ACh receptors are present on the surface of lymphocytes, to investigate whether ACh in the blood acts on lymphocytes and participates in the modulation of immune responses. Expand
Defective immune responses in mice lacking LUBAC‐mediated linear ubiquitination in B cells
TLDR
It is suggested that LUBAC‐mediated linear polyubiquitination is essential for B‐cell development and activation, possibly via canonical NF‐κB and ERK activation induced by the TNF receptor superfamily, but not by the BCR. Expand
Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines
TLDR
The results suggest that the major portion of ACh in the circulating blood originates from T-lymphocytes, which is localized in circulating mononuclear leukocytes in humans. Expand
Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator
TLDR
It is demonstrated that activation of T-lymphocytes up-regulates ACh synthesis in the blood, and suggest that ACh plays an important role as a neuroimmunomodulator besides its role as an neurotransmitter. Expand
Upregulation of mRNA Encoding the M5 Muscarinic Acetylcholine Receptor in Human T- and B-Lymphocytes During Immunological Responses
TLDR
This represents the first demonstration that immunological stimulation leads to M5 mAChR gene expression in lymphocytes, and the effects of lymphocyte activation on expression of mA ChR mRNA are examined. Expand
Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate).
TLDR
It is confirmed that the antiproliferative activity correlates with cellular MEK inhibition and observed significant antitumor activity with daily oral dosing of 1 in a tumor xenograft model, which led to the selection of 1 for clinical development. Expand
Development of T cell receptor αβ‐bearing T cells in the submersion organ culture of murine fetal thymus at high oxygen concentration
TLDR
The results indicated that the fetal thymus microenvironment was potentially capable of supporting the development of both γδ and αβ T cells, and that skewing to one of these lineages was determined by an additional factor(s) such as the concentration of O2 dissolved in the medium. Expand
Expression of multiple mRNA species for choline acetyltransferase in human T-lymphocytes.
TLDR
The findings suggest that the mechanisms regulating ChAT mRNA expression in T-lymphocytes differ from those in cholinergic neurons. Expand
Involvement of the Endogenous Cannabinoid 2 Ligand 2-Arachidonyl Glycerol in Allergic Inflammation
TLDR
The data strongly suggest that endogenous CB2 ligands upregulated upon disease progression in allergic models are involved in aberrant alterations of both inflammatory responses and tissue cell growth. Expand
Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2
TLDR
It was shown that JTP-74057 directly bound to MEK1 and MEK2 and allosterically inhibited their kinase activities, and that its inhibitory characteristics were similar to those of the known and different chemotype of MEK inhibitors PD0325901 and U0126. Expand
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