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The 3-hydroxy group of lanosterol is essential for orienting the substrate in the substrate site of cytochrome P-45014DM (Lanosterol 14α-demethylase)
Interaction of lanosterol, 3-epilanosterol, 3-oxolanosta-8,24-diene, 3-methylenelanost-8-ene and lanosterol acetate with cytochrome P -450 14DM were studied. The cytochrome mediated theExpand
Cobalt-Catalyzed Allylic C(sp3)-H Carboxylation with CO2.
TLDR
This allylic C(sp3)-H carboxylation showcases a facile synthesis of γ-butyrolactones from simple allylarenes via short steps through Sharpless asymmetric dihydroxylation. Expand
Sequential protocol for C(sp3)-H carboxylation with CO2: transition-metal-catalyzed benzylic C-H silylation and fluoride-mediated carboxylation.
TLDR
A sequential protocol by employing a nitrogen-directed, metal-assisted, C-H activation/catalytic silylation reaction in conjunction with fluoride-mediated carboxylation with CO(2) gas was established, which proceeded only at the benzylic C(sp(3))-Si bond, which is advantageous for further manipulations of the products. Expand
Catalytic asymmetric carbon-carbon bond formation: asymmetric synthesis of cis-decalin derivatives by palladium-catalyzed cyclization of prochiral alkenyl iodides
Une synthese asymetrique catalytique utilisant la reaction de type Heck a ete realisee pour la premiere fois, donnant un des derives de cis-decaline avec plus de 46% d'exces enantiomere
Nickel-mediated carboxylative cyclization of enynes
Nickel-mediated carboxylative cyclization of α,ω-enyne using carbon dioxide was investigated. Oxidative cycloaddition of enynes having an electron withdrawing group on alkene to a zero-valent nickelExpand
Rhodium(I)-Catalyzed Intramolecular Hydroacylation of 4,6-Dienals: Novel Synthesis of Cycloheptenones.
Rhodium(I)-Catalyzed Synthesis of Cycloheptenones Yo ihiro Oonishi,a Miwako Mori,b Yoshihiro Sato*a a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan FaxExpand
Nickel‐Promoted Highly Regioselective Carboxylation of Aryl Ynol Ether and Its Application to the Synthesis of Chiral β‐Aryloxypropionic Acid Derivatives.
A new method for the enantioselective synthesis of the optically active title propionic acid derivatives involving the synthesis of α-substituted-β-aryloxyacrylic acid derivatives from aryl ynolExpand
Catalytic enantioselective silylation of N-sulfonylimines: asymmetric synthesis of α-amino acids from CO2 via stereospecific carboxylation of α-amino silanes.
TLDR
A catalytic enantioselective silylation of N-tert-butylsulfonylimines using a Cu-secondary diamine complex was demonstrated, providing a new synthetic protocol for optically active α-amino acids from gaseous CO2 and imines in the presence of a catalytic amount of a chiral source. Expand
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