Learn More
Twenty hemiplegic patients were studied with transcranial magnetic stimulation (TMS). Motor evoked potentials (MEPs) of the biceps brachii (BB) and the abductor pollicis brevis muscles (APB) were recorded on both sides simultaneously. TMS was carried out with an 8-shaped coil over different scalp positions in the intact hemisphere. Bilateral MEPs of BB were(More)
BACKGROUND Duplications involving the methyl-CpG-binding protein 2 gene (MECP2) locus at Xq28 have been frequently identified in male patients who exhibit a phenotype unique from that of Rett syndrome, which is mainly characterized by severe mental retardation, recurrent infections, and epilepsy. This combination of features is recognized as MECP2(More)
We studied a 13-year-old girl with unilateral extensive cortical dysplasia who had mild hemiparesis with mirror movement and no sensory deficit. Transcranial focal magnetic stimulation (TMS) to the unaffected hemisphere elicited bilateral motor evoked potentials (MEPs) of the abductor pollicis brevis muscle (APB) with similar latency and amplitude. The(More)
Entropy measurement can discriminate among complex systems, including deterministic, stochastic and composite systems. We evaluated the changes of approximate entropy (ApEn) in signals of the electroencephalogram (EEG) during sleep. EEG signals were recorded from eight healthy volunteers during nightly sleep. We estimated the values of ApEn in EEG signals(More)
OBJECTIVE Gaucher disease (GD) is a lysosomal storage disease characterized by a deficiency of glucocerebrosidase. Although enzyme-replacement and substrate-reduction therapies are available, their efficacies in treating the neurological manifestations of GD are negligible. Pharmacological chaperone therapy is hypothesized to offer a new strategy for(More)
Early-onset epileptic encephalopathies (EOEE) are severe neurological disorders characterized by frequent seizures accompanied by developmental regression or retardation. Whole-exome sequencing of 12 patients together with five pairs of parents and subsequent Sanger sequencing in additional 328 EOEE patients identified two de novo frameshift and one(More)
Transcranial magnetic stimulation (TMS) has been used to describe cortical plasticity after unilateral cerebral lesions. The objective of this study was to find out whether cortical plasticity occurs after bilateral cerebral lesions. We investigated central motor reorganization for the arm and leg muscles in cerebral palsy (CP) patients with bilateral(More)
We describe a technique of lumbosacral magnetic stimulation (MS) using an 8-shaped coil in 44 normal children and 7 normal adults on the lower limb muscles. In most child subjects and some adult subjects, we observed two peaks in amplitude of the motor evoked potential (MEP) following MS when the coil was moved caudally from Th8 to S2. The rostral peaks of(More)
OBJECTIVE To elucidate the generator sources of high-frequency oscillations of somatosensory evoked potentials (SEPs), we recorded somatosensory evoked high-frequency oscillations directly from the human cerebral cortex. SUBJECTS AND METHODS Seven patients, 6 with intractable partial epilepsy and one with a brain tumor, were studied. With chronically(More)