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Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
TLDR
Repeated daily restraint stress for 21 days caused apical dendrites of CA3 pyramidal neurons to atrophy, while basal CA3 dendrite levels did not change. Expand
Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events
TLDR
The data provide insights into the molecular mechanisms underlying the susceptibility and adaptation to chronic stress within the brain, suggesting that epigenetic modifications of Gdnf, along with genetic and environmental factors, contribute to behavioral responses to stress. Expand
Phenytoin prevents stress‐ and corticosterone‐induced atrophy of CA3 pyramidal neurons
TLDR
Repeated daily restraint stress and daily corticosterone administration to adult male Sprague‐Dawley rats leads to decreases in the number of branch points and length of dendrites of CA3 pyramidal neurons of the hippocampal formation, consistent with a model in which stress‐ and cortic testosterone‐induced CA3 dendritic atrophy is produced by excitatory amino acids released from the mossy fibers. Expand
Early Life Stress Enhances Behavioral Vulnerability to Stress through the Activation of REST4-Mediated Gene Transcription in the Medial Prefrontal Cortex of Rodents
TLDR
The results suggest that the activation of REST4-mediated gene regulation in the mPFC during postnatal development is involved in stress vulnerability. Expand
Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin
TLDR
The surprising finding of a similar effect of both drugs to reduce serotonin transporter sites labelled by [3H]paroxetine suggest the possibility of a common action for these two drugs in spite of their opposite effects on serotonin re-uptake. Expand
Altered expression of neurotrophic factors in patients with major depression.
TLDR
The results suggest that the changes in the expression levels of GDNF, ARTN, and NT-3 mRNAs might be state-dependent and associated with the pathophysiology of major depression. Expand
Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA‐mediated down‐regulation of the glucocorticoid receptor
TLDR
The results suggest that F344 rats could be a useful animal model for studying vulnerability to repeated stress, and that miR‐18a‐mediated down‐regulation of GR translation may be an important factor to be considered in susceptibility to stress‐related disorders. Expand
Reduced Glucocorticoid Receptor α Expression in Mood Disorder Patients and First-Degree Relatives
TLDR
The results suggest that reduced GRalpha mRNA expression might be trait-dependent and associated with the pathophysiology of mood disorders. Expand
Altered gene expression of histone deacetylases in mood disorder patients
TLDR
The influence of lentiviral vector infection on developing Purkinje neurons is assessed and the usefulness and limitation of lentIViral vectors for their application to basic research as well as gene therapy is discussed. Expand
Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain
TLDR
The effects of adrenalectomy and replacement with glucocorticoid receptor agonists on serotonin (5-HT) 5- HT1A and 5-HT2 receptor binding in rat brain were evaluated and the expression of 5-ht transporter mRNA was unchanged in the raphe nucleus as measured by in situ hybridization. Expand
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