Yoshifumi Nakane

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Homozygotes of the quail silver mutation, which have plumage color changes, also display a unique phenotype in the eye: during early embryonic development, the retinal pigment epithelium (RPE) spontaneously transdifferentiates into neural retinal tissue. Mitf is considered to be the responsible gene and to function similarly to the mouse microphthalmia(More)
The rat demyelination (dmy) mutation serves as a unique model system to investigate the maintenance of myelin, because it provokes severe myelin breakdown in the central nervous system (CNS) after normal postnatal completion of myelination. Here, we report the molecular characterization of this mutation and discuss the possible pathomechanisms underlying(More)
Panda and dotted white mutant plumage colors of Japanese quail (Coturnix japonica) were found to be controlled by the autosomal alleles. Both mutants showed white plumage with colored spots or patches, but they were easily distinguishable by size and location of the colored areas and the color and markings of the pigmented feathers. At hatching also they(More)
The demyelination (dmy) rat is a unique mutant exhibiting severe myelin breakdown in the central nervous system (CNS). In this study, we conducted immunohistochemical and morphometrical investigations in the dmy rat. From around 6 weeks of age, the affected rats developed ataxia especially in the hindlimbs. Afterwards, ataxia worsened rapidly, resulting in(More)
We recently found a spontaneous tremor mutant in an outbred colony of Sprague-Dawley rats. The tremor behavior was exhibited from around 3 weeks of age and inherited as an autosomal recessive trait. The mutant rats had variously sized vacuoles in the neuropil and white matter throughout the central nervous system, especially in the brain stem, cerebellum,(More)
Body-tremorous rats were found in a colony of WTC-tm rats and a new coisogenic mutant strain void of the tm mutation was established. Histological analysis revealed that these rat mutants had abnormal vacuoles in the red nucleus of the midbrain, the reticular formation in the brain stem, and the white matter of the cerebellum and spinal cord. Electron(More)
Recently spaces for the aged have become more wide spread as the population of them has increased. Most of the spaces, however, are originally provided for the young and, accordingly, can not be considered preferable environments for the aged. From this point of view, the authors aimed at the visual environments for the aged and carried out experimental(More)
Experiments were conducted to examine the visibility of different floor levels from a stumbling point of view. The test subjects were the elderly and the young, and we compared the difference between the two. We investigated eye movement while they were scanning the different floor levels. The results were as follows: 1) The height of different floor levels(More)
We carried out a comparative study of a group of schizophrenic patients and a group of patients with depression, looking at 1) symptoms and social behaviors, 2) the performance level of socially expected activities and free-time activities, and 3) the level of expectations of family members with respect to patients' activities according to the results of a(More)
This sub-study of the WHO Determinants of Outcome of Severe Mental Disorders research project was aimed at characterizing the behavioral and expressive qualities of schizophrenia in two highly diverse cultures. Early research has indicated that the core elements involving affect, perceptual and cognitive dysfunction in schizophrenia are highly similar in(More)