Yoshiaki Tanaka

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Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, has been implicated in the activation of macrophages. Here we show that Jmjd3 is essential for M2 macrophage polarization in response to(More)
The ongoing enhancement of mobile devices capabilities and advanced technologies has largely contributed to the huge increase of wireless traffic demand. Mobile network operators around the world are struggling to manage this new era of higher generation networks by finding new means and strategies to implement in order to meet the explosion in traffic(More)
The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establishment of Treg cell-specific CpG(More)
The MANETs have been experiencing exponential growth in the past decade. However, their vulnerability to various attacks make the security problem extremely prominent for its distributed, self-organized and infrastructure independent nature. As concerning this problem, trust management schemes are proposed as a common way to detect and isolate the(More)
We performed a genome-wide analysis of transcriptional start sites (TSSs) in human genes by multifaceted use of a massively parallel sequencer. By analyzing 800 million sequences that were obtained from various types of transcriptome analyses, we characterized 140 million TSS tags in 12 human cell types. Despite the large number of TSS clusters (TSCs), the(More)
Understanding the genome sequence-specific positioning of nucleosomes is essential to understand various cellular processes, such as transcriptional regulation and replication. As a typical example, the 10-bp periodicity of AA/TT and GC dinucleotides has been reported in several species, but it is still unclear whether this feature can be observed in the(More)
Nucleosome configuration in eukaryotic genomes is an important clue to clarify the mechanisms of regulation for various nuclear events. In the past few years, numerous computational tools have been developed for the prediction of nucleosome positioning, but there is no third-party benchmark about their performance. Here we present a performance evaluation(More)
WDM optical networks represent the direction to the future high capacity wide-area network applications. By reconfiguring the logical topology, network resources utilization can be optimized corresponding to the traffic pattern changes. From the viewpoint of network operation, the complexity of reconfiguration should be minimized as well. We consider the(More)