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Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, has been implicated in the activation of macrophages. Here we show that Jmjd3 is essential for M2 macrophage polarization in response to(More)
The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establishment of Treg cell-specific CpG(More)
This paper proposes a bandwidth allocation system by using GVA (Generalized Vickrey Auction), which can be used for leasing lines, reselling lines, or allocating bandwidth to individual users. In the proposed system, network resources, which are composed of many links at various bandwidths, are regarded as multiple items with multiple units. It is described(More)
The ongoing enhancement of mobile devices capabilities and advanced technologies has largely contributed to the huge increase of wireless traffic demand. Mobile network operators around the world are struggling to manage this new era of higher generation networks by finding new means and strategies to implement in order to meet the explosion in traffic(More)
The utility of a contents delivery network depends on the waiting time. This paper deals with the priority control of contents delivery networks from the viewpoint of utility. First, a subjective evaluation experiment on image downloading is carried out to obtain the relationship between the waiting time and the utility. From the results, a function of the(More)
In leased line services used by ISPs (Inter-net Service Providers) the bandwidth is fixed, but the traffic changes dynamically. To address this, we propose an auction method for the dynamic allocation of bandwidth to ISPs sharing backbone networks. By the method, backbone networks can be used effectively as each ISP is able to secure bandwidth according to(More)
The aim of this study was to evaluate the contrast enhancement, pharmacokinetics, dialyzability, and safety of gadodiamide in patients on hemodialysis. Thirteen hemodialysis patients with abdominal disease were examined after receiving intravenous gadodiamide (0.1 mmol/kg body weight) by magnetic resonance imaging (MRI) and were dialyzed at l, 3, 5, and 8(More)
We performed a genome-wide analysis of transcriptional start sites (TSSs) in human genes by multifaceted use of a massively parallel sequencer. By analyzing 800 million sequences that were obtained from various types of transcriptome analyses, we characterized 140 million TSS tags in 12 human cell types. Despite the large number of TSS clusters (TSCs), the(More)
The characteristics of Pneumocystis carinii pneumonia (PCP) in patients with connective tissue diseases (CTDs) were examined retrospectively. Nine patients were enrolled in this study. Their mean age was 57.1 years. All the patients received a high-dose steroid or immunosuppressant. The onset (mean 6.6 days) of fever, cough, breathlessness, and geographical(More)