Yoshiaki Sugiyama

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We propose a novel method for identifying and classifying the functions of transmembrane (TM) proteins based on their TM topology [the number of TM segments (tms), the loop length and the N-terminus location]. In this method, the TM topology is expressed as a string of '0' and '1', and this is designated the binary topology pattern (BTP). We focused on TM(More)
About one fourth of genes in genomes has been known to encode transmembrane (TM) proteins (TMPs) [2, 6, 8]. Although TMPs have important functions playing an essential role in life, detailed and comprehensive analysis of their functions haven’t been carried out yet. In this study, we tried to develop a novel method to classify and identify TMP functions(More)
G protein-coupled receptors (GPCRs) play extremely important functions in our body which are mainly to transduce chemical signals across cell membranes, therefore GPCRs are one of the target proteins in the biomedical field. GPCRs are found in large numbers in most eukaryotic genomes, although the only completely known three-dimensional structure in these(More)
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