Yoshiaki Nakao

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OBJECTIVE To determine whether early and late postoperative facial nerve function can be predicted on the basis of electromyographic responses in acoustic neuroma surgery. SETTING Prospective blinded study. DESIGN Tertiary referral center. PATIENTS AND METHODS Burst and train electromyographic responses were recorded intraoperatively during the last(More)
OBJECTIVE This study aimed to determine whether postoperative facial nerve paralysis or surgical manipulation causing paralysis could be predicted on train responses during intraoperative facial nerve monitoring in acoustic neuroma surgery. STUDY DESIGN AND SETTING This was a prospective study performed at a tertiary referral center. PATIENTS AND(More)
A series of cysteine-bearing hydrophobic polypeptides analogous to a light-harvesting one betapolypeptide (LH1beta) from the LH1 complex from the purple photosynthetic bacterium, Rhodobacter sphaeroides, was synthesized using an Escherichia coli expression system. The cysteine was placed in the C- or N-terminal regions of the polypeptide to investigate the(More)
Much attention has been paid to the cross-coupling reaction of organosilicon compounds due to their stability, non-toxicity, and natural abundance of silicon. In addition, the silicon-based cross-coupling has many advantages over other cross-coupling protocols. Successful examples of the silicon-based cross-coupling reaction are reviewed, focusing(More)
A new method which facilitates identification of the internal auditory canal during the middle cranial fossa approach is described. This method uses illumination of the external auditory meatus as a guide to the internal auditory canal. When the external auditory meatus is illuminated by a light source system such that used for a flexible fiberscope, areas(More)
A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitriles having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the(More)
Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. A variety of substituents on both alkenes and pyridine are tolerated to give linear 4-alkylpyridines in modest to good yields. The addition across styrene, on the other hand,(More)
A large number of pharmaceuticals, natural products, and optical materials contain a pyridine nucleus. Thus, the functionalization of pyridines is an important transformation in organic synthesis. However, due to the low reactivity of pyridine derivatives toward aromatic electrophilic substitution reactions such as the FriedelCrafts reaction, additional(More)