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Identification of ACA‐28, a 1′‐acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells
ACA‐28, a synthetic derivative of 1′‐acetoxychavicol acetate (ACA), which is a natural ginger compound, effectively inhibited the growth of melanoma cancer cells wherein ERK MAPK signaling is hyperactivated due to mutations in the upstream activating regulators. Expand
Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit.
An aqueous acetone extract from the fruit of Alpinia galanga demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells, and the active compounds 1-3 inhibited tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA expressions could be the mechanism of melanogenesis inhibitory activity. Expand
Acetoxybenzhydrols as highly active and stable analogues of 1'S-1'-acetoxychavicol, a potent antiallergic principal from Alpinia galanga.
More stable and potent analogue, 4-(methoxycarbonyloxyphenylmethyl)phenyl acetate (16), has been developed and strongly inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production. Expand
Labdane-Type Diterpenes, Galangalditerpenes A–C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga
The melanogenesis inhibitory activities in theophylline-stimulated murine B16 melanoma 4A5 cells of these isolates, including the new diterpenes, were found to be more than 6–87-fold higher than that of arbutin, a commercially available positive control. Expand
Total Synthesis of γ-Alkylidenebutenolides, Potent Melanogenesis Inhibitors from Thai Medicinal Plant Melodorum fruticosum.
All naturally occurring butenolides were assigned as partial racemic mixtures with respect to the chiral center at C-6, and the melanogenesis inhibitory activities of S- and R-1-4 were evaluated, with all shown to be potent inhibitors. Expand
Two new aromatic glycosides, elengiosides A and B, from the flowers of Mimusops elengi
Two new aromatic glycosides, elengiosides A (1) and B (2), were isolated from the methanolic extract of the flowers of Mimusops elengi (Sapotaceae) together with 26 known compounds. TheirExpand
Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth.
Seven new acylated iridoid glycosides, picrorhizaosides A-G (1-7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to sixExpand
Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth.
Three new acylated phenylethanoid glycosides, kurroaosides A, B, and C, and a newAcylated cucurbitane-type triterpene glycoside, kURroaoside D, were isolated from a methanol extract of the rhizomes of Picrorhiza kur roa Royle ex Benth, with no cytotoxicity being observed at the effective concentrations. Expand
Quantitative Determination of Principal Aporphine and Benzylisoquinoline Alkaloids Due to Blooming State in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Hyaluronidase Inhibitory Activity
Using a recently developed analytical protocol, distributions of 5 aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and 5Expand
Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity
Geranylated coumarin constituents, kayeassamin I and mammeasins E and F, were newly isolated from the methanol extract of the flowers of Mammea siamensis and were found to inhibit testosterone 5α-reductase. Expand