Yoshiaki Isobe

Hitoo Nishino4
Hideki Hida2
Noritaka Aihara2
Hiroshi Watari1
4Hitoo Nishino
2Hideki Hida
2Noritaka Aihara
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Neural stem/progenitor cells (NPCs) reside in the subventricular zone (SVZ) and dentate gyrus in the adult mammalian brain. It has been reported that endogenous NPCs are activated after brain insults such as ischemic stroke. We investigated whether proliferation and migration of endogenous NPCs are increased after a collagenase-induced small intracerebral(More)
Authentication based on biometrics is being applied to control physical access to high-security facilities. Recently, with the recent rapid growth of information system technologies, applications for accessing databases or business workflow systems have begun to use biometrics. These applications need to implement measures to counter threats to security. In(More)
Metabolic activity in the suprachiasmatic nucleus (SCN), a center of biological rhythm, is higher during the daytime than at night. The rhythmic oscillation in the SCN is feedback controlled by the CLOCK/BMAL1 heterodimer binding to the E-box in target genes (e.g., Arg- vasopressin). Similar transcriptional regulation by NPAS2/BMAL1 heterodimer formation(More)
Fetal striatal cell suspensions were grafted stereotaxically into the infarcted striatum of rats, and reconstruction of striatopallidal GABA transmission and behavior were investigated. Occlusion of the middle cerebral artery (MCA) for one hour induced ischemic infarcts mainly in the lateral striatum, as detected by magnetic resonance imaging (MRI) and(More)
During the analysis of wheel running activity, we found that corticosterone (1 mg/100 g BW) injection decreased wheel activity, while dexamethasone (0.1 mg/100 g) increased the activity. To clarify the functional differences between corticosterone and dexamethasone, we measured Arg-vasopressin (AVP) release from the suprachiasmatic nucleus (SCN) slice(More)
Melatonin, which is released from the pineal gland, influences many physiological events concerned with circadian rhythm. Body temperature levels and rhythmicity are tightly coupled with locomotor activity. To understand the functions of melatonin, we determined the effects of melatonin injection on locomotor activity measured by running-wheel activity and(More)
Serotonin (5-HT) and glutamate are concerned with the input pathways to the suprachiasmatic nucleus (SCN), a center of biological rhythms in mammals. Arg-vasopressin (AVP) is one of the output paths from the SCN to other brain areas. Functional relations of 5-HT on glutamate release, which stimulates AVP release, were therefore analyzed in an SCN slice(More)
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