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The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. Expand
Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues.
It is demonstrated that the incorporation of two Nala residues into the central position of the hydrophobic helix face of noncell-selective alpha-helical peptides is a promising strategy for the rational design of intracellular, cell- selective antimicrobial peptides. Expand
Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides
The peptides (defensins, cathelicidins, RNase7, dermcidin) and other mediators (toll-like receptor, IL-1 and IL-17) that comprise the host defense against S. aureus skin infection, as well as the various mechanisms by which S.aureus evades host defenses are discussed. Expand
Protease Inhibitors from Plants with Antimicrobial Activity
Protease inhibitors from plants potently inhibited the growth of a variety of pathogenic bacterial and fungal strains and are therefore excellent candidates for use as the lead compounds for the development of novel antimicrobial agents. Expand
Marine Peptides and Their Anti-Infective Activities
The structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present are presented. Expand
Gram-positive bacteria specific properties of silybin derived fromSilybum marianum
The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria, more potent than silymarin II. Expand
Effects of dietary supplementation of antimicrobial peptide-A3 on growth performance, nutrient digestibility, intestinal and fecal microflora and intestinal morphology in weanling pigs
The results obtained indicate that the AMP-A3 had beneficial effects on growth performance, CTTAD of nutrients, intestinal morphology and intestinal and fecal microflora and can be used as a potential alternative to antibiotic growth promoters in weanling pigs. Expand
Higher biofilm formation in multidrug-resistant clinical isolates of Staphylococcus aureus.
The results suggest that the multidrug-resistant clinical isolates of S. aureus have a greater likelihood of developing biofilms on medical devices. Expand
Fungicidal effect of indolicidin and its interaction with phospholipid membranes.
The results suggest that indolicidin may exert its fungicidal activity by disrupting the structure of cell membranes, via direct interaction with the lipid bilayers, in a salt-dependent and energy-independent manner. Expand
Antimicrobial activity studies on a trypsin-chymotrypsin protease inhibitor obtained from potato.
A 5.6 kDa trypsin-chymotrypsin protease inhibitor was isolated from the tubers of the potato (Solanum tuberosum L cv. Gogu) by extraction of the water-soluble fraction, dialysis, ultrafiltration, andExpand