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The aims of this cross-sectional study were (i) to compare the overall glucose metabolism between early onset and late onset Alzheimer's disease in a large sample of patients; and (ii) to investigate the pattern of glucose metabolism as a function of dementia severity in early onset versus late onset Alzheimer's disease, using a statistical parametric(More)
We have demonstrated a highly-efficient cladding-pumped ytterbium-doped fiber laser generating 1.36 kW of continuous-wave output power at 1.1 mum with 83% slope efficiency and near diffraction-limited beam quality. The laser was end-pumped through both fiber ends and showed no evidence of roll-over even at the highest output power, which was limited only by(More)
The lateral hypothalamus is part of an efferent system that modifies pain at the spinal cord dorsal horn, but the mechanisms by which lateral hypothalamus-induced antinociception occur are not fully understood. Previous work has shown that antinociception produced from electrical stimulation of the lateral hypothalamus is mediated in part by spinally(More)
Frontotemporal dementia (FTD) often coexists with motor neuron disease (MND). To characterize glucose hypometabolism in patients with FTD with MND (FTD/MND), the authors compared the glucose metabolism of 8 patients with FTD/MND with that of 29 patients with FTD. All of the patients with FTD/MND showed glucose hypometabolism only in the frontal area,(More)
We present a cladding-pumped single-frequency, single-mode erbium:ytterbium codoped fiber master-oscillator power amplifier source generating up to 151 W of continuous-wave output power at 1563 nm with 33% slope efficiency and 20 dB gain. This source was also tunable and had a stable operation range of 1546 to 1566 nm at an output power level in excess of(More)
We report the generation of white light from a picosecond pump by efficient four-wave mixing processes. A 530 nm green source based on a frequency-doubled Yb-doped fiber laser generates strong red and blue sidebands in the secondary cores of a holey fiber with large air-filling factor. Phase matching is attributed to birefringence within the(More)
PURPOSE To evaluate the efficacy of two-phase dynamic helical computed tomography (CT), including the gastric mucosal phase, for detection of early gastric carcinoma with typical hyperattenuating and atypical nonhyperattenuating enhancement patterns. METHOD Two-phase helical CT scanning was performed using the water-filling method as negative oral(More)
The Met receptor tyrosine kinase, found to be constitutively activated in many tumors, has become a leading target for cancer therapy. Disruptions in Met downregulation have been associated with aggressive tumor progression with several therapeutic strategies addressing this aspect of Met biology. Castias B-lineage lymphoma (Cbl) E3 ligase-mediated(More)
OBJECTIVE The purpose of this study was to describe the CT features of gastrointestinal involvement in seven patients with Henoch-Schönlein syndrome. CONCLUSION Although the incidence of Henoch-Schönlein syndrome is low, it should be considered when CT scans show multifocal areas of bowel-wall thickening, mesenteric edema, vascular engorgement, and(More)
Anodic oxidation and oxide films of titanium in the new electrolyte of calcium glycerophosphate (Ca-GP) and calcium acetate (CA) were investigated by galvanostatic mode, SEM, XRD and EPMA. The anodic oxide film displayed porosity, intermediate roughness, and high crystallinity. Also, the oxide film is enriched with Ca and P and high in thickness without(More)