Yoon-Seok Choi

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The identification of breast tumor initiating cells (BTICs) is important for the diagnosis and therapy of breast cancers. This study was undertaken to evaluate whether the extra domain-B of fibronectin (EDB-FN) could be used as a new biomarker for BTICs and whether EDB-FN targeting superparamagnetic iron oxide nanoparticles (SPIONs) could be used as a(More)
SUMMARY We propose a new genetic fuzzy discretization method with feature selection for the pattern classification problems. Traditional discretization methods categorize a continuous attribute into a number of bins. Because they are made on crisp discretization, there exists considerable information loss. Fuzzy discretization allows overlapping intervals(More)
We propose a genetic fuzzy discretization method for continuous numerical attributes. Traditional discretization methods categorize the continuous attributes into a number of bins. Because they are made on crisp discretization, there exists considerable information loss. Fuzzy discretization allows overlapping intervals and reflects linguistic(More)
The noninvasive imaging of dendritic cells (DCs) migrated into lymph nodes (LNs) can provide helpful information on designing DCs-based immunotherapeutic strategies. This study is to investigate the influence of transduction of human ferritin heavy chain (FTH) and green fluorescence protein (GFP) genes on inherent properties of DCs, and the feasibility of(More)
BACKGROUND Cancer stem cells (CSCs) are highly tumorigenic and are responsible for tumor progression and chemoresistance. Noninvasive imaging methods for the visualization of CSC populations within tumors in vivo will have a considerable impact on the development of new CSC-targeting therapeutics. METHODOLOGY/PRINCIPAL FINDINGS In this study, human breast(More)
The epithelial-mesenchymal transition (EMT) plays important roles in tumor progression to metastasis. Thus, the development of an imaging probe that can monitor transient periods of the EMT process in live cells is required for a better understanding of metastatic process. Inspired by the fact that the mRNA expression levels of zinc finger E-box-binding(More)
We present a genetic feature selection method for the optimization of an image set for producing real-time photomosaics. A photomosaic is an image that is divided into grid cells, each of which is replaced with another image of an appropriate color pattern. Construction of a photomosaic requires a large set of tile images with different patterns. However, a(More)
BACKGROUND AND OBJECTIVES Placement of drug-eluting stents (DES) can be complicated by stent thrombosis; prophylactic antiplatelet therapy has been used to prevent such events. We evaluated the efficacy of cilostazol with regard to stent thrombosis as adjunctive antiplatelet therapy. SUBJECTS AND METHODS A total of 1,315 patients (846 males, 469 females)(More)
BACKGROUND Even though the olfactory function usually is improved or unchanged after ethmoidectomy, some patients complain of olfactory disturbance, which may be caused by direct injury to the olfactory nerves. However, the detailed anatomic pathway of the olfactory nerves that leave the olfactory mucosa and after going through the cribriform plate insert(More)
PURPOSE The aim of this study is to determine the diagnostic and prognostic role of baseline spinal magnetic resonance imaging (MRI) in patients with multiple myeloma. MATERIALS AND METHODS We enrolled patients newly diagnosed with multiple myeloma from 2004-2011 at a single center. Abnormal MRI findings that were not detected in radiographs have been(More)